Association of selenoprotein S gene polymorphism with ischemic stroke in a Chinese case-control study

被引：13

作者：

Li, Xiao-Xia ^{[1
]}

Guan, Hong-Jun ^{[1
]}

Liu, Jian-Ping ^{[2
]}

Guo, Yu-Peng ^{[1
]}

Yang, Yong ^{[1
]}

Niu, Ying-Ying ^{[1
]}

Yao, Li-Yan ^{[1
]}

Yang, Yin-Dong ^{[3
]}

Yue, Hong-Yu ^{[3
]}

Meng, Li-Li ^{[3
]}

Cui, Xin-Yu ^{[1
]}

Yang, Xiao-Wei ^{[1
]}

Gao, Jin-Xiao ^{[1
]}

机构：

[1] Mudanjiang Med Univ, Dept Prevent Med, Mudanjiang, Heilongjiang, Peoples R China

[2] Shenzhen Ctr Dis Control & Prevent, Shenzhen, Guangdong, Peoples R China

[3] Mudanjiang Med Univ, Hongqi Hosp, Mudanjiang, Heilongjiang, Peoples R China

来源：

BLOOD COAGULATION & FIBRINOLYSIS | 2015年 / 26卷 / 02期

基金：

中国国家自然科学基金;

关键词：

case-control study; ischemic stroke; polymorphism; selenoprotein S; SERUM-AMYLOID-A; ENDOPLASMIC-RETICULUM STRESS; C-REACTIVE PROTEIN; GENOMEWIDE ASSOCIATION; RISK; SUSCEPTIBILITY; EXPRESSION; SEVERITY; DISEASE; IMPACT;

D O I：

10.1097/MBC.0000000000000202

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Previous studies showed that selenoprotein S (SELS) was associated with a range of inflammatory markers, and its gene expression was influenced by a polymorphism in the promoter region. The genetic basis of the ischemic stroke has now been largely determined, so the aim of the study was to examine the role of SELS genetic variants in the ischemic stroke risk in a Chinese population. We conducted a case-control study with 239 ischemic stroke patients and 240 controls. Two single-nucleotide polymorphisms (SNPs) in SELS genes were analyzed for association with the risk of ischemic stroke in the Chinese Han population. No evidence of ischemic stroke association was observed with the SNP rs34713741. Interestingly, the strongest evidence showed that SELS SNP rs4965814 was associated with ischemic stroke (P<0.05). We found a significant association with increased ischemic stroke risk in women carrying the CC genotype of rs4965814 [hazard ratio: 2.43(1.03-5.75)]; a similar trend was also found in men carrying the TC genotype of rs4965814 [hazard ratio: 1.81(1.06-3.08)]. SNP rs4965814 of SELS may affect the susceptibility to ischemic stroke. Understanding the inflammatory mechanisms of ischemic stroke may give new therapeutic targets to pharmacologists. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.

引用

页码：131 / 135

页数：5

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