Time to Think Outside the (Genetic) Box

被引：9

作者：

Issa, Jean-Pierre J. ^{[1
]}

Garber, Judy E. ^{[2
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA

[2] Dana Farber Canc Inst, Boston, MA 02115 USA

来源：

CANCER PREVENTION RESEARCH | 2011年 / 4卷 / 01期

关键词：

BREAST-CANCER; PROMOTER METHYLATION; DNA METHYLATION; LYNCH SYNDROME; COLORECTAL-CANCER; RISK; INDIVIDUALS; PATHOLOGY; CARRIERS; BRCA1;

D O I：

10.1158/1940-6207.CAPR-10-0348

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Many patients develop cancers that have clinical features of inherited syndromes (e. g., young age of onset and unique pathology) but lack mutations in the genes characteristic of the disease. In this issue of the journal, Wong et al. report that somatic epigenetic inactivation could explain some such cases in the setting of BRCA1-associated breast cancer. Here, we discuss the implications of this work in terms of the etiology, risk, and potential prevention of cancer. Cancer Prev Res; 4(1); 6-8. (C) 2011 AACR.

引用

页码：6 / 8

页数：3

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