Transcriptional Regulation of Telomerase Reverse Transcriptase (TERT) by MYC

被引：35
作者：
Khattar, Ekta [1 ]
Tergaonkar, Vinay [1 ,2 ,3 ,4 ]
机构：
[1] ASTAR, Inst Mol & Cell Biol, Lab NFKB Signaling, Singapore, Singapore
[2] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore, Singapore
[3] Univ South Australia, Ctr Canc Biol, Adelaide, SA, Australia
[4] SA Pathol, Adelaide, SA, Australia
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2017年 / 5卷
关键词：
TERT; Myc; telomerase; transcription; cancer; NF-KAPPA-B; MESSENGER-RNA EXPRESSION; ESTROGEN-RECEPTOR-ALPHA; C-MYC; CATALYTIC SUBUNIT; HTERT EXPRESSION; MEDIATED TRANSACTIVATION; PROMOTER REACTIVATION; DIRECT ACTIVATION; GENE-EXPRESSION;
D O I：
10.3389/fcell.2017.00007
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Telomerase elongates telomeres and is crucial for maintaining genomic stability. While stem cells and cancer cells display high telomerase activity, normal somatic cells lack telomerase activity primarily due to transcriptional repression of telomerase reverse transcriptase (TERT), the catalytic component of telomerase. Transcription factor binding, chromatin status as well as epigenetic modifications at the TERT promoter regulates TERT transcription. Myc is an important transcriptional regulator of TERT that directly controls its expression by promoter binding and associating with other transcription factors. In this review, we discuss the current understanding of the molecular mechanisms behind regulation of TERT transcription by Myc. We also discuss future perspectives in investigating the regulation of Myc at TERT promoter during cancer development.
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页数：7
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