共 47 条
Topoisomerase II Inhibitors Can Enhance Baculovirus-Mediated Gene Expression in Mammalian Cells through the DNA Damage Response
被引:22
作者:

Liu, Ming-Kun
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Natl Tsing Hua Univ, Inst Bioinformat & Struct Biol, Hsinchu 300, Taiwan Natl Tsing Hua Univ, Inst Bioinformat & Struct Biol, Hsinchu 300, Taiwan

Lin, Jhe-Jhih
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Natl Tsing Hua Univ, Inst Bioinformat & Struct Biol, Hsinchu 300, Taiwan Natl Tsing Hua Univ, Inst Bioinformat & Struct Biol, Hsinchu 300, Taiwan

Chen, Chung-Yung
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机构:
Chung Yuan Christian Univ, Dept Biosci Technol, Chungli 320, Taiwan Natl Tsing Hua Univ, Inst Bioinformat & Struct Biol, Hsinchu 300, Taiwan

Kuo, Szu-Cheng
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Inst Prevent Med, Natl Def Med Ctr, Taipei 237, Taiwan Natl Tsing Hua Univ, Inst Bioinformat & Struct Biol, Hsinchu 300, Taiwan

Wang, Yu-Ming
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Inst Prevent Med, Natl Def Med Ctr, Taipei 237, Taiwan Natl Tsing Hua Univ, Inst Bioinformat & Struct Biol, Hsinchu 300, Taiwan

Chan, Hong-Lin
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Natl Tsing Hua Univ, Inst Bioinformat & Struct Biol, Hsinchu 300, Taiwan Natl Tsing Hua Univ, Inst Bioinformat & Struct Biol, Hsinchu 300, Taiwan

Wu, Tzong Yuan
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h-index: 0
机构:
Chung Yuan Christian Univ, Dept Biosci Technol, Chungli 320, Taiwan
China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung 404, Taiwan Natl Tsing Hua Univ, Inst Bioinformat & Struct Biol, Hsinchu 300, Taiwan
机构:
[1] Natl Tsing Hua Univ, Inst Bioinformat & Struct Biol, Hsinchu 300, Taiwan
[2] Chung Yuan Christian Univ, Dept Biosci Technol, Chungli 320, Taiwan
[3] Inst Prevent Med, Natl Def Med Ctr, Taipei 237, Taiwan
[4] China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung 404, Taiwan
关键词:
baculovirus;
BacMam;
DNA damage response;
topoisomerase;
p53;
PROTEIN EXPRESSION;
HEPATOCELLULAR-CARCINOMA;
INSECT;
DELIVERY;
VECTORS;
ENTRY;
HEPATOCYTES;
SEQUENCE;
BREAKS;
D O I:
10.3390/ijms17060931
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
BacMam is an insect-derived recombinant baculovirus that can deliver genes into mammalian cells. BacMam vectors carrying target genes are able to enter a variety of cell lines by endocytosis, but the level of expression of the transgene depends on the cell line and the state of the transduced cells. In this study, we demonstrated that the DNA damage response (DDR) could act as an alternative pathway to boost the transgene(s) expression by BacMam and be comparable to the inhibitors of histone deacetylase. Topoisomerase II (Top II) inhibitor-induced DDR can enhance the CMV-IE/enhancer mediated gene expression up to 12-fold in BacMam-transduced U-2OS cells. The combination of a Top II inhibitor, VM-26, can also augment the killing efficiency of a p53-expressing BacMam vector in U-2OS osteosarcoma cells. These results open a new avenue to facilitate the application of BacMam for gene delivery and therapy.
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页数:15
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