Anaemia of prematurity Pathophysiology and treatment

被引:117
作者
Strauss, Ronald G. [1 ]
机构
[1] Univ Iowa, Coll Med, Iowa City, IA 52242 USA
关键词
Anaemia of prematurity; Neonatal RBC transfusions; Recombinant human erythropoietin; Neonatal transfusion outcomes; BIRTH-WEIGHT INFANTS; BLOOD-CELL TRANSFUSIONS; RECOMBINANT-HUMAN-ERYTHROPOIETIN; NEONATAL INTENSIVE-CARE; PRETERM INFANTS; RANDOMIZED-TRIAL; REQUIREMENTS; METAANALYSIS; GUIDELINES; EFFICACY;
D O I
10.1016/j.blre.2010.08.001
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Most infants with birth weight <1 0 kg are given multiple red blood cell (RBC) transfusions within the first few weeks of life The anaemia of prematurity is caused by untimely birth occurring before placental iron transport and fetal erythropolesis are complete by phlebotomy blood losses taken for laboratory testing by low plasma levels of erythropoietin due to both diminished production and accelerated catabolism by rapid body growth and need for commensurate increase in red cell volume/mass and by disorders causing RBC losses due to bleeding and/or hemolysis RBC transfusions are the mainstay of therapy with recombinant human erythropoietin largely unused because it fails to substantially diminish RBC transfusion needs despite exerting substantial erythropoietic effects on neonatal marrow (C) 2010 Elsevier Ltd All rights reserved
引用
收藏
页码:221 / 225
页数:5
相关论文
共 42 条
  • [1] Amin AA, 2002, SAUDI MED J, V23, P287
  • [2] [Anonymous], 2009, NATL VITAL STAT REP
  • [3] A comparison of high versus low dose recombinant human erythropoietin versus blood transfusion in the management of anaemia of prematurity in a developing country
    Avent, M
    Cory, BJ
    Galpin, J
    Ballot, DE
    Cooper, PA
    Sherman, G
    Davies, VA
    [J]. JOURNAL OF TROPICAL PEDIATRICS, 2002, 48 (04) : 227 - 233
  • [4] Bednarek FJ, 1998, J PEDIATR-US, V133, P601, DOI 10.1016/s0022-3476(98)70097-6
  • [5] Randomized trial of liberal versus restrictive guidelines for red blood cell transfusion in preterm infants
    Bell, EF
    Strauss, RG
    Widness, JA
    Mahoney, LT
    Mock, DM
    Seward, VJ
    Cress, GA
    Johnson, KJ
    Kromer, IJ
    Zimmerman, MB
    [J]. PEDIATRICS, 2005, 115 (06) : 1685 - 1691
  • [6] DECREASED RESPONSE OF PLASMA-IMMUNOREACTIVE ERYTHROPOIETIN TO AVAILABLE OXYGEN IN ANEMIA OF PREMATURITY
    BROWN, MS
    GARCIA, JF
    PHIBBS, RH
    DALLMAN, PR
    [J]. JOURNAL OF PEDIATRICS, 1984, 105 (05) : 793 - 798
  • [7] Erythropoietin mRNA expression in human fetal and neonatal tissue
    Dame, C
    Fahnenstich, H
    Freitag, P
    Hofmann, D
    Abdul-Nour, T
    Bartmann, P
    Fandrey, J
    [J]. BLOOD, 1998, 92 (09) : 3218 - 3225
  • [8] Effect of early versus late administration of human recombinant erythropoietin on transfusion requirements in premature infants:: Results of a randomized, placebo-controlled, multicenter trial
    Donato, H
    Vain, N
    Rendo, P
    Vivas, N
    Prudent, L
    Larguía, M
    Digregorio, J
    Vecchiarelli, C
    Valverde, R
    García, C
    Subotovsky, P
    Solana, C
    Gorenstein, A
    [J]. PEDIATRICS, 2000, 105 (05) : 1066 - 1072
  • [9] Variability on red blood cell transfusion practices among Brazilian neonatal intensive care units
    dos Santos, Amelia M. N.
    Guinsburg, Ruth
    Procianoy, Renato S.
    Sadeck, Lilian dos S. R.
    Netto, Abimael Aranha
    Rugolo, Ligia M.
    Luz, Jorge H.
    Bomfim, Olga
    Martinez, Francisco E.
    de Almeida, Maria Fernanda B.
    [J]. TRANSFUSION, 2010, 50 (01) : 150 - 159
  • [10] Red blood cell transfusions in very and extremely low birthweight infants under restrictive transfusion guidelines: is exogenous erythropoietin necessary?
    Franz, AR
    Pohlandt, F
    [J]. ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 2001, 84 (02): : F96 - F100