Anaemia of prematurity Pathophysiology and treatment

被引：117
作者：
Strauss, Ronald G. [1 ]
机构：
[1] Univ Iowa, Coll Med, Iowa City, IA 52242 USA
来源：
BLOOD REVIEWS | 2010年 / 24卷 / 06期
关键词：
Anaemia of prematurity; Neonatal RBC transfusions; Recombinant human erythropoietin; Neonatal transfusion outcomes; BIRTH-WEIGHT INFANTS; BLOOD-CELL TRANSFUSIONS; RECOMBINANT-HUMAN-ERYTHROPOIETIN; NEONATAL INTENSIVE-CARE; PRETERM INFANTS; RANDOMIZED-TRIAL; REQUIREMENTS; METAANALYSIS; GUIDELINES; EFFICACY;
D O I：
10.1016/j.blre.2010.08.001
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Most infants with birth weight <1 0 kg are given multiple red blood cell (RBC) transfusions within the first few weeks of life The anaemia of prematurity is caused by untimely birth occurring before placental iron transport and fetal erythropolesis are complete by phlebotomy blood losses taken for laboratory testing by low plasma levels of erythropoietin due to both diminished production and accelerated catabolism by rapid body growth and need for commensurate increase in red cell volume/mass and by disorders causing RBC losses due to bleeding and/or hemolysis RBC transfusions are the mainstay of therapy with recombinant human erythropoietin largely unused because it fails to substantially diminish RBC transfusion needs despite exerting substantial erythropoietic effects on neonatal marrow (C) 2010 Elsevier Ltd All rights reserved
引用
收藏
页码：221 / 225
页数：5
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