INO80 and SWR1 complexes: the non-identical twins of chromatin remodelling

被引：50

作者：

Willhoft, Oliver ^{[1
]}

Wigley, Dale B. ^{[1
]}

机构：

[1] Imperial Coll London, Fac Med, Dept Infect Dis, Sect Struct & Synthet Biol, London SW7 2AZ, England

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2020年 / 61卷

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

ACTIN-RELATED PROTEIN; HISTONE H2A; SACCHAROMYCES-CEREVISIAE; DNA TRANSLOCATION; CRYSTAL-STRUCTURE; SUBUNIT; SWI/SNF; SWITCH; CORE; ACETYLATION;

D O I：

10.1016/j.sbi.2019.09.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The INO80 family of chromatin remodellers are multisubunit complexes that perform a variety of tasks on nucleosomes. Family members are built around a heterohexamer of RuvB-like protein, an ATP-dependent DNA translocase,nuclear actin and actin-related proteins, and a few complex-specific subunits. They modify chromatin in a number of ways including nucleosome sliding and exchange of variant histones. Recent structural information on INO80 and SWR1 complexes has revealed similarities in the basic architecture of the complexes. However, structural and biochemical data on the complexes bound to nucleosomes reveal these similarities to be somewhat superficial and their biochemical activities and mechanisms are very different. Consequently, the INO80 family displays a surprising diversity of function that is based upon a similar structural framework.

引用

页码：50 / 58

页数：9

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