Skin-controlled release lipid nanosystems of pranoprofen for the treatment of local inflammation and pain

被引：15
作者：
Rincon, Maria [1 ]
Calpena, Ana C. [1 ,2 ]
Clares, Beatriz [2 ,3 ]
Espina, Marta [1 ,2 ]
Garduno-Ramirez, Maria L. [4 ]
Rodriguez-Lagunas, Maria J. [5 ]
Garcia, Maria L. [1 ,2 ]
Abrego, Guadalupe [6 ]
机构：
[1] Univ Barcelona, Fac Pharm & Food Sci, Dept Pharm Pharmaceut Technol & Phys Chem, Barcelona, Spain
[2] Univ Barcelona, Inst Nanosci & Nanotechnol IN2UB, Barcelona, Spain
[3] Univ Granada, Dept Pharm & Pharmaceut Technol, Fac Pharm, Granada, Spain
[4] Univ Autonoma Estado Morelos, Ctr Invest Quim, Cuernavaca, Morelos, Mexico
[5] Univ Barcelona, Fac Pharm & Food Sci, Dept Biochem & Physiol, Barcelona, Spain
[6] Univ El Salvador, Fac Chem & Pharm, Dept Chem & Instrumental Anal, San Salvador, El Salvador
来源：
NANOMEDICINE | 2018年 / 13卷 / 19期
关键词：
anti-inflammatory efficacy; dermal delivery; experimental design; inflammation; local action; nanostructured lipid carriers; osteoarthritis; pranoprofen; skin irritation; skin permeation; LOADED PLGA NANOPARTICLES; IN-VITRO; BIOPHARMACEUTICAL PROFILE; KNEE OSTEOARTHRITIS; EX-VIVO; DELIVERY; MANAGEMENT; DESIGN; RECOMMENDATIONS; GLYCEROSOMES;
D O I：
10.2217/nnm-2018-0195
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Aim: The design and development of pranoprofen (PF) nanostructured lipid carriers (NLCs) for topical treatment of local inflammation and pain. Materials & methods: PF-NLCs were designed and optimized by central rotatable composite design. A physicochemical characterization was addressed. Release and skin permeation were performed in Franz diffusion cells. in vivo anti-inflammatory efficacy was assayed in mice and tolerance study in humans. Results: PF-NLCs F7 and F10 provided sustained release, good stability and optimal skin retention avoiding systemic undesired side effects. Anti-inflammatory activity was enhanced, suggesting an improved efficacy as compared with standard formulation. No skin irritancy was detected. Conclusion: Topical PF-NLCs F7 and F10 could be effective and safe new therapeutic tools for the treatment of local inflammation and pain. [GRAPHICS] .
引用
收藏
页码：2397 / 2413
页数：17
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