A new generation XIAP inhibitor induces apoptosis of human myeloma cells and synergises with conventional and novel anti-myeloma therapeutics

被引:0
|
作者
Khong, Tiffany [1 ]
Spencer, Andrew [1 ]
机构
[1] Alfred Hosp, Myeloma Res Grp, Melbourne, Vic, Australia
关键词
D O I
10.1182/blood.V110.11.4787.4787
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
4787
引用
收藏
页码:270B / 270B
页数:1
相关论文
共 50 条
  • [41] Bone morphogenetic protein (BMP)-2 induces apoptosis in human myeloma cells
    Kawamura, C
    Kizaki, M
    Ikeda, Y
    LEUKEMIA & LYMPHOMA, 2002, 43 (03) : 635 - 639
  • [42] EPILEPSY DOSES OF VALPROATE COMBINED WITH THE ANTI-HELMINTHIC, NICLOSAMIDE, SYNERGISTICALLY KILL MYELOMA CELLS: A POTENT NEW ANTI-MYELOMA DRUG COMBINATION.
    Ferretti, L.
    Raffles, S.
    Giles, H.
    Jankute, M.
    Merrick, B.
    Bunce, C.
    Drayson, M.
    Khanim, F.
    HAEMATOLOGICA, 2013, 98 : 592 - 592
  • [43] Oral Dosing of the Novel Proteasome Inhibitor CEP-18770 Shows Marked Anti-Myeloma Effects in SCID-Hu Models of Multiple Myeloma
    Sanchez, Eric
    Li, Mingjie
    Steinberg, Jeffrey A.
    Wang, Cathy S.
    Shen, Jing
    Bonavida, Benjamin
    Li, Zhi-Wei
    Chen, Haiming
    Berenson, James R.
    BLOOD, 2009, 114 (22) : 730 - 731
  • [44] A novel agent SL-401 induces anti-myeloma activity by targeting plasmacytoid dendritic cells, osteoclastogenesis and cancer stem-like cells
    Ray, A.
    Das, D. S.
    Song, Y.
    Macri, V.
    Richardson, P.
    Brooks, C. L.
    Chauhan, D.
    Anderson, K. C.
    LEUKEMIA, 2017, 31 (12) : 2652 - 2660
  • [45] A novel agent SL-401 induces anti-myeloma activity by targeting plasmacytoid dendritic cells, osteoclastogenesis and cancer stem-like cells
    A Ray
    D S Das
    Y Song
    V Macri
    P Richardson
    C L Brooks
    D Chauhan
    K C Anderson
    Leukemia, 2017, 31 : 2652 - 2660
  • [46] Sinomenine derivative YL064: a novel STAT3 inhibitor with promising anti-myeloma activity
    Wang, Yingying
    Wu, Linlin
    Cai, Haiyan
    Lei, Hu
    Ma, Chun-Min
    Yang, Li
    Xu, Hanzhang
    Zhu, Qi
    Yao, Zhujun
    Wu, Yingli
    CELL DEATH & DISEASE, 2018, 9
  • [47] The novel c-MYC inhibitor IDP-121 exhibits strong anti-myeloma effect.
    Krzeminski, Patryk
    Gonzalez-Mendez, Lorena
    San Segundo, Laura
    Mogollon, Pedro
    Diaz, Andrea
    Hernandez-Garcia, Susana
    Algarin, Macarena
    Martin-Sanchez, Montserrat
    Cochete, Luis
    Paino, Teresa
    Esteban, Santiago
    Nevola, Laura
    Gutierrez, Norma C.
    Mateos, Ma-Victoria
    Garayoa, Mercedes
    Ocio, Enrique M.
    CANCER RESEARCH, 2021, 81 (13)
  • [48] A novel NF-kB inhibitor induces apoptosis to multiple myeloma cells;: A comparison with proteasome inhibitor and analysis in vitro and in vivo.
    Tatetsu, H
    Hata, H
    Nakamura, M
    Okuno, Y
    Matsuno, F
    Umezawa, K
    Sonoki, T
    Mitsuya, H
    BLOOD, 2003, 102 (11) : 927A - 928A
  • [49] A novel PDK1 inhibitor, JX06, inhibits glycolysis and induces apoptosis in multiple myeloma cells
    Kawano, Yawara
    Sasano, Takayuki
    Arima, Yuichiro
    Kushima, Saki
    Tsujita, Kenichi
    Matsuoka, Masao
    Hata, Hiroyuki
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2022, 587 : 153 - 159
  • [50] LP-118, a Novel BCL2 Inhibitor, Shows Potent in Vitro Anti-Myeloma Activity
    Fonseca, Rodrigo
    Zhu, Yuan Xiao
    Bergsagel, P. Leif
    Chesi, Marta
    Pandey, Akhilesh
    Mangalaparthi, Kiran
    Chen, Yi
    Tan, Felai
    Anthony, Stephen P.
    Chen, Yu
    Shen, Yue
    Dai, Bing
    Braggio, Esteban
    Fonseca, Rafael
    BLOOD, 2022, 140 : 7129 - 7130