Real-time impedance feedback to enhance cutaneous gene electrotransfer in a murine skin model

被引:1
作者
Atkins, Reginald M. [1 ,2 ]
Fawcett, Timothy J. [1 ,2 ,3 ]
Gilbert, Richard [1 ,2 ]
Hoff, Andrew M. [2 ,4 ]
Connolly, Richard [1 ,2 ]
Brown, Douglas W. [5 ]
Jaroszeski, Mark J. [1 ,2 ,6 ]
机构
[1] Univ S Florida, Dept Chem Biol & Mat Engn, 4202 E Fowler Ave ENG 030, Tampa, FL 33620 USA
[2] Univ S Florida, Ctr Mol Delivery USF, 4202 E Fowler Ave ENG 030, Tampa, FL 33620 USA
[3] Univ S Florida, Res Comp, 4202 E Fowler Ave ENG 030, Tampa, FL 33620 USA
[4] Univ S Florida, Dept Elect Engn, 4202 E Fowler Ave ENG 030, Tampa, FL 33620 USA
[5] Georgia Inst Technol, Sch Elect & Comp Engn, 777 Atlantic Dr NW, Atlanta, GA 30332 USA
[6] Univ S Florida, Dept Med Engn, 4202 E Fowler Ave ENG 030, Tampa, FL 33620 USA
基金
美国国家卫生研究院;
关键词
Gene electrotransfer; Electroporation; Gene therapy; Skin; Gene delivery; PLASMID DNA DELIVERY; ELECTROPORATION; SPECTROSCOPY; ELECTROPERMEABILIZATION; CELLS;
D O I
10.1016/j.bioelechem.2021.107885
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Funding Research reported in this publication was primarily supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) of the National Institutes of Health under award number R21AR061136 (Jaroszeski, PI) and in part by the National Institute of Biomedical Imaging and Bioengineering under award number R01EB027497. Support was also provided by the USF Center for Molecular Delivery, USF Chemical, Biological, and Materials Engineering Department, and the USF Medical Engineering Department. Approximately 80% of the total study costs were financed with federal money. The content of this publication is solely the
引用
收藏
页数:9
相关论文
共 32 条
  • [1] Gene transfer into muscle by electroporation in vivo
    Aihara, H
    Miyazaki, J
    [J]. NATURE BIOTECHNOLOGY, 1998, 16 (09) : 867 - 870
  • [2] Atkins R.M., 2012, THESIS U S FLORIDA
  • [3] Impedance spectroscopy as an indicator for successful in vivo electric field mediated gene delivery in a murine model
    Atkins, Reginald M.
    Fawcett, Timothy J.
    Gilbert, Richard
    Hoff, Andrew M.
    Connolly, Richard
    Brown, Douglas W.
    Llewellyn, Anthony J.
    Jaroszeski, Mark J.
    [J]. BIOELECTROCHEMISTRY, 2017, 115 : 33 - 40
  • [4] Development of an adaptive electroporation system for intratumoral plasmid DNA delivery
    Brown, Douglas W.
    Bahrami, Arya J.
    Canton, David A.
    Mukhopadhyay, Anandaroop
    Campbell, Jean S.
    Pierce, Robert H.
    Connolly, Richard J.
    [J]. BIOELECTROCHEMISTRY, 2018, 122 : 191 - 198
  • [5] Cancer Electrogene Therapy with Interleukin-12
    Cemazar, Maja
    Jarm, Tomaz
    Sersa, Gregor
    [J]. CURRENT GENE THERAPY, 2010, 10 (04) : 300 - 311
  • [6] Effectiveness of Non-penetrating Electroporation Applicators to Function as Impedance Spectroscopy Electrodes
    Connolly, Richard J.
    Rey, Jose I.
    Jaroszeski, Mark J.
    Hoff, Andrew M.
    Gilbert, Richard
    Llewellyn, J. Anthony
    [J]. IEEE TRANSACTIONS ON DIELECTRICS AND ELECTRICAL INSULATION, 2009, 16 (05) : 1348 - 1355
  • [7] Phase I Trial of Interleukin-12 Plasmid Electroporation in Patients With Metastatic Melanoma
    Daud, Adil I.
    DeConti, Ronald C.
    Andrews, Stephanie
    Urbas, Patricia
    Riker, Adam I.
    Sondak, Vernon K.
    Munster, Pamela N.
    Sullivan, Daniel M.
    Ugen, Kenneth E.
    Messina, Jane L.
    Heller, Richard
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (36) : 5896 - 5903
  • [8] Electrical impedance spectroscopy study of biological tissues
    Dean, D. A.
    Ramanathan, T.
    Machado, D.
    Sundararajan, R.
    [J]. JOURNAL OF ELECTROSTATICS, 2008, 66 (3-4) : 165 - 177
  • [9] Evaluation of a Novel Non-Penetrating Electrode for Use in DNA Vaccination
    Donate, Amy
    Coppola, Domenico
    Cruz, Yolmari
    Heller, Richard
    [J]. PLOS ONE, 2011, 6 (04):
  • [10] Topical gene transfer into rat skin using electroporation
    Dujardin, N
    Van der Smissen, P
    Préat, V
    [J]. PHARMACEUTICAL RESEARCH, 2001, 18 (01) : 61 - 66