Endogenous carbon monoxide production in disease

被引：84
作者：
Owens, Elizabeth Oesterling [1 ]
机构：
[1] US EPA, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA
来源：
CLINICAL BIOCHEMISTRY | 2010年 / 43卷 / 15期
关键词：
Endogenous carbon monoxide; Heme oxygenase; Carboxyhemoglobin; EXHALED AIR; CARBOXYHEMOGLOBIN LEVELS; HEME CATABOLISM; ARTERIAL CARBOXYHEMOGLOBIN; ERYTHROCYTE DESTRUCTION; NITRIC-OXIDE; IN-VIVO; BILIRUBIN; BLOOD; MARKER;
D O I：
10.1016/j.clinbiochem.2010.07.011
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Carbon monoxide (CO) in tissues and cells can originate from inhalation of CO or endogenously. Endogenous production, carboxyhemoglobin (COHb) formation, and exhaled CO levels are influenced by physiological factors, including disease. It is suggested that endogenous CO production can be used as a biomarker for oxidative and inflammatory processes. Also, endogenous CO can contribute to increased body burden of CO, which may both disrupt normal CO signaling cascades and increase the risk of CO toxicity. (C) 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码：1183 / 1188
页数：6
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