Simian Immunodeficiency Virus-Specific CD8+ T Cells Recognize Vpr- and Rev-Derived Epitopes Early after Infection

被引：19

作者：

Sacha, Jonah B. ^{[1
]}

Buechler, Matthew B. ^{[1
]}

Newman, Laura P. ^{[1
]}

Reed, Jason ^{[1
]}

Wallace, Lyle T. ^{[1
]}

Loffredo, John T. ^{[1
]}

Wilson, Nancy A. ^{[1
]}

Watkins, David I. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Pathol & Lab Med, Madison, WI 53715 USA

来源：

JOURNAL OF VIROLOGY | 2010年 / 84卷 / 20期

关键词：

I DOWN-REGULATION; VIRAL PROTEIN; LYMPHOCYTES; REPLICATION; HIV-1; ESCAPE; GAG; EXPRESSION; RESPONSES; VIRIONS;

D O I：

10.1128/JVI.01357-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The kinetics of CD8(+) T cell epitope presentation contribute to the antiviral efficacy of these cells yet remain poorly defined. Here, we demonstrate presentation of virion-derived Vpr peptide epitopes early after viral penetration and prior to presentation of Vif-derived epitopes, which required de novo Vif synthesis. Two Rev epitopes exhibited differential presentation kinetics, with one Rev epitope presented within 1 h of infection. We also demonstrate that cytolytic activity mirrors the recognition kinetics of infected cells. These studies show for the first time that Vpr- and Rev-specific CD8(+) T cells recognize and kill simian immunodeficiency virus (SIV)-infected CD4(+) T cells early after SIV infection.

引用

页码：10907 / 10912

页数：6

共 31 条

[1] Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia [J].

Allen, TM ;

O'Connor, DH ;

Jing, PC ;

Dzuris, JL ;

Mothé, BR ;

Vogel, TU ;

Dunphy, E ;

Liebl, ME ;

Emerson, C ;

Wilson, N ;

Kunstman, KJ ;

Wang, XC ;

Allison, DB ;

Hughes, AL ;

Desrosiers, RC ;

Altman, JD ;

Wolinsky, SM ;

Sette, A ;

Watkins, DI .

NATURE, 2000, 407 (6802) :386-390

[2] Epitope-dependent avidity thresholds for cytotoxic T-lymphocyte clearance of virus-infected cells [J].

Bennett, Michael S. ;

Ng, Hwee L. ;

Dagarag, Mirabelle ;

Ali, Ayub ;

Yang, Otto O. .

JOURNAL OF VIROLOGY, 2007, 81 (10) :4973-4980

[3] The stoichiometry of Gag protein in HIV-1 [J].

Briggs, JAG ;

Simon, MN ;

Gross, I ;

Kräusslich, HG ;

Fuller, SD ;

Vogt, VM ;

Johnson, MC .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2004, 11 (07) :672-675

[4] Subdominant CD8+ T-cell responses are involved in durable control of AIDS virus replication [J].

Friedrich, Thomas C. ;

Valentine, Laura E. ;

Yant, Levi J. ;

Rakasz, Eva G. ;

Piaskowski, Shari M. ;

Furlott, Jessica R. ;

Weisgrau, Kimberly L. ;

Burwitz, Benjamin ;

May, Gemma E. ;

Leon, Enrique J. ;

Soma, Taeko ;

Napoe, Gnankang ;

Capuano, Saverio V., III ;

Wilson, Nancy A. ;

Watkins, David I. .

JOURNAL OF VIROLOGY, 2007, 81 (07) :3465-3476

[5] A molecularly cloned, pathogenic, neutralization-resistant simian immunodeficiency virus, SIVsmE543-3 [J].

Hirsch, V ;

AdgerJohnson, D ;

Campbell, B ;

Goldstein, S ;

Brown, C ;

Elkins, WR ;

Montefiori, DC .

JOURNAL OF VIROLOGY, 1997, 71 (02) :1608-1620

[6] HIV controls the selective packaging of genomic, spliced viral and cellular RNAs into virions through different mechanisms [J].

Houzet, Laurent ;

Paillart, Jean Christophe ;

Smagulova, Fatima ;

Maurel, Stephan ;

Morichaud, Zakia ;

Marquet, Roland ;

Mougel, Marylene .

NUCLEIC ACIDS RESEARCH, 2007, 35 (08) :2695-2704

[7] CD8+Lymphocytes Control Viral Replication in SIVmac239-Infected Rhesus Macaques without Decreasing the Lifespan of Productively Infected Cells [J].

Klatt, Nichole R. ;

Shudo, Emi ;

Ortiz, Alex M. ;

Engram, Jessica C. ;

Paiardini, Mirko ;

Lawson, Benton ;

Miller, Michael D. ;

Else, James ;

Pandrea, Ivona ;

Estes, Jacob D. ;

Apetrei, Cristian ;

Schmitz, Joern E. ;

Ribeiro, Ruy M. ;

Perelson, Alan S. ;

Silvestri, Guido .

PLOS PATHOGENS, 2010, 6 (01)

[8] The antiviral efficacy of simian immunodeficiency virus-specific CD8+ T cells is unrelated to epitope specificity and is abrogated by viral escape [J].

Loffredo, John T. ;

Burwitz, Benjamin J. ;

Rakasz, Eva G. ;

Spencer, Sean P. ;

Stephany, Jason J. ;

Vela, Juan Pablo Giraldo ;

Martin, Sarah R. ;

Reed, Jason ;

Piaskowski, Shari M. ;

Furlott, Jessica ;

Weisgrau, Kim L. ;

Rodrigues, Denise S. ;

Soma, Taeko ;

Napoe, Gnankang ;

Friedrich, Thomas C. ;

Wilson, Nancy A. ;

Kallas, Esper G. ;

Watkins, David I. .

JOURNAL OF VIROLOGY, 2007, 81 (06) :2624-2634

[9] Two MHC Class I Molecules Associated with Elite Control of Immunodeficiency Virus Replication, Mamu-B*08 and HLA-B*2705, Bind Peptides with Sequence Similarity [J].

Loffredo, John T. ;

Sidney, John ;

Bean, Alex T. ;

Beal, Dominic R. ;

Bardet, Wilfried ;

Wahl, Angela ;

Hawkins, Oriana E. ;

Piaskowski, Shari ;

Wilson, Nancy A. ;

Hildebrand, William H. ;

Watkins, David I. ;

Sette, Alessandro .

JOURNAL OF IMMUNOLOGY, 2009, 182 (12) :7763-7775

[10] AIDS virus-specific CD8+ T lymphocytes against an immunodominant cryptic epitope select for viral escape [J].

Maness, Nicholas J. ;

Valentine, Laura E. ;

May, Gemma E. ;

Reed, Jason ;

Piaskowski, Shari M. ;

Soma, Taeko ;

Furlott, Jessica ;

Rakasz, Eva G. ;

Friedrich, Thomas C. ;

Price, David A. ;

Gostick, Emma ;

Hughes, Austin L. ;

Sidney, John ;

Sette, Alessandro ;

Wilson, Nancy A. ;

Watkins, David I. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (11) :2505-2512

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