Design, synthesis, and biological evaluation of a novel series of thiazole derivatives based on pyrazoline as anticancer agents

This study deals with the design and synthesis of new pyrazoline-thiazole scaffold as promising anti-cancer agents, with the goal of building new compounds with combinations of various heterocyclic moieties. The pyrazoline-thiazole scaffold was synthesized via cyclization of the chalcone derivative with thiosemicarbazide to afford the corresponding thioamide 5, which was the key precursor for synthesis of the compounds 7-15. Three cancer cell lines (MCF-7, HepG-2 and A549) were used to examine in vitro anticancer activities of the recently synthesized compounds. Three compounds 7c, 9c, and 11d were found to show the most promising anti-cancer activity against three cell lines.