Lipoxygenase inhibitory constituents from Indigofera oblongifolia

被引：28
作者：
Sharif, A
Ahmed, E
Malik, A [1 ]
Riaz, N
Afza, N
Nawaz, SA
Arshad, M
Shah, MR
Choudhary, MI
机构：
[1] Univ Karachi, Int Ctr Chem Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan
[2] Pakistan Council Sci & Ind Res, Labs Karachi Complex, Pharmaceut Res Ctr, Karachi 75280, Pakistan
来源：
ARCHIVES OF PHARMACAL RESEARCH | 2005年 / 28卷 / 07期
关键词：
Indigofera oblongifolia; Fabaceae; lipoxygenase inhibition;
D O I：
10.1007/BF02977339
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Indigin, alkylated xanthene (1) and indigoferic acid (2) have been isolated from the chloroform soluble fraction of Indigofera oblongifolia, along with P-sitosterol (3) and 3-hydroxybenzoic acid (4), which are reported for the first time from this species. Their structures were determined through spectroscopic techniques. Both the new compounds 1 and 2 showed significant activity against enzyme lipoxygenase, while 2 further showed moderate inhibition against BChE.
引用
收藏
页码：761 / 764
页数：4
相关论文
共 13 条
[1]   Screening of Yemeni medicinal plants for antibacterial and cytotoxic activities [J].
Ali, NAA ;
Jülich, WD ;
Kusnick, C ;
Lindequist, U .
JOURNAL OF ETHNOPHARMACOLOGY, 2001, 74 (02) :173-179
[2]  
Anam EM, 1997, INDIAN J CHEM B, V36, P118
[3]  
BERNARD AA, 1977, J ORG CHEM, V42, P725
[4]   Antibacterial and antifungal activity of small protein of Indigofera oblongifolia leaves [J].
Dahot, MU .
JOURNAL OF ETHNOPHARMACOLOGY, 1999, 64 (03) :277-282
[5]   Cyclooxygenases and lipoxygenases as potential targets for treatment of pancreatic cancer [J].
Ding, XZ ;
Tong, WG ;
Adrian, TE .
PANCREATOLOGY, 2001, 1 (04) :291-299
[6]   A NEW AND RAPID COLORIMETRIC DETERMINATION OF ACETYLCHOLINESTERASE ACTIVITY [J].
ELLMAN, GL ;
COURTNEY, KD ;
ANDRES, V ;
FEATHERSTONE, RM .
BIOCHEMICAL PHARMACOLOGY, 1961, 7 (02) :88-&
[7]   CHEMISTRY OF THE ANNONACEAE .26. THE UVARISESQUITERPENES, A NOVEL TYPE OF BENZYLATED SESQUITERPENE FROM UVARIA-ANGOLENSIS [J].
MUHAMMAD, I ;
WATERMAN, PG .
JOURNAL OF NATURAL PRODUCTS, 1988, 51 (04) :719-724
[8]   Pakistolides A and B, novel enzyme inhibitory and antioxidant dimeric 4-(glucosyloxy)benzoates from Berchemia pakistanica [J].
Mukhtar, N ;
Malik, A ;
Riaz, N ;
Iqbal, K ;
Tareen, RB ;
Khan, SN ;
Nawaz, SA ;
Siddiqui, J ;
Choudhary, MI .
HELVETICA CHIMICA ACTA, 2004, 87 (02) :416-424
[9]   Cholinesterase-inhibiting withanolides from Ajuga bracteosa [J].
Riaz, N ;
Malik, A ;
Aziz-ur-Rehman ;
Nawaz, SA ;
Muhammad, P ;
Choudhary, MI .
CHEMISTRY & BIODIVERSITY, 2004, 1 (09) :1289-1295
[10]   SHIKIMATE-DERIVED METABOLITES .11. THE STRUCTURE OF FERRUDIOL - A HIGHLY OXIDIZED CONSTITUENT OF UVARIA-FERRUGINEA [J].
SCHULTE, GR ;
GANEM, B ;
CHANTRAPROMMA, K ;
KODPINID, M ;
SUDSUANSRI, K .
TETRAHEDRON LETTERS, 1982, 23 (03) :289-292
12