Islet transplantation reverses the effects of maternal diabetes on mouse oocytes

被引：18

作者：

Cheng, Pan-Pan ^{[1
]}

Xia, Jun-Jie ^{[1
]}

Wang, Hai-Long ^{[2
]}

Chen, Ji-Bing ^{[2
]}

Wang, Fei-Yu ^{[1
]}

Zhang, Ye ^{[2
]}

Huang, Xin ^{[1
]}

Zhang, Quan-Jun ^{[3
]}

Qi, Zhong-Quan ^{[1
]}

机构：

[1] Xiamen Univ, Organ Transplantat Inst, Xiamen 361005, Fujian Province, Peoples R China

[2] Xiamen Univ, Coll Med, Basic Med Dept, Xiamen 361005, Fujian Province, Peoples R China

[3] Xiamen Univ, Zhongshan Hosp, Yanwu Branch, Xiamen 361005, Fujian Province, Peoples R China

来源：

REPRODUCTION | 2011年 / 141卷 / 04期

关键词：

CELL TRANSPLANTATION; SPINDLE CHECKPOINT; MEIOTIC REGULATION; MELLITUS; ACTIVATION; RAT; INSULIN; EMBRYO; METABOLISM; MATURATION;

D O I：

10.1530/REP-10-0370

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Maternal diabetes adversely affects preimplantation embryo development and oocyte maturation. Thus, it is important to identify ways to eliminate the effects of maternal diabetes on preimplantation embryos and oocytes. The objectives of this study were to investigate whether islet transplantation could reverse the effects of diabetes on oocytes. Our results revealed that maternal diabetes induced decreased ovulation; increased the frequency of meiotic spindle defects, chromosome misalignment, and aneuploidy; increased the relative expression levels of Mad2 and Bub1; and enhanced the sensitivity of oocytes to parthenogenetic activation. Islet transplantation prevented these detrimental effects. Therefore, we concluded that islet transplantation could reverse the effects of diabetes on oocytes, and that this technique may be useful to treat the fundamental reproductive problems of women with diabetes mellitus. Reproduction (2011) 141 417-424

引用

页码：417 / 424

页数：8

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