Antiphospholid Antibody Syndrome and Hb E/Beta Thalassemia Disease Post-Allogeneic Stem Cell Transplantation

被引：1

作者：

Sirachainan, Nongnuch ^{[1
]}

Pakakasama, Samart ^{[1
]}

Hongeng, Suradej ^{[1
]}

Chuansumrit, Ampaiwan ^{[1
]}

Tuntiyatorn, Lojana ^{[2
]}

Vilaiyuk, Soamarat ^{[1
]}

机构：

[1] Ramathibodi Hosp, Div Hematol Oncol, Fac Med, Bangkok 10300, Thailand

[2] Ramathibodi Hosp, Dept Radiol, Fac Med, Bangkok 10300, Thailand

来源：

PEDIATRIC BLOOD & CANCER | 2011年 / 57卷 / 01期

关键词：

graft versus host disease; thalassemia; transplantation; VERSUS-HOST-DISEASE; BONE-MARROW TRANSPLANTATION; LUPUS ANTICOAGULANT;

D O I：

10.1002/pbc.23020

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report a 10-year-old male with Hb E/Beta thalassemia disease who developed chronic graft-versus-host disease (cGVHD) of antiphospholipid antibody syndrome after successful allogeneic stem cell transplantation (SCT). He exhibited a recurrent ischemic stroke on day 368 post-SCT while on cyclosporine A, azathioprine, and prednisolone. The immunosuppressive agents were switched to pulse methylprednisolone, tacolimus, mycophenolate mofetil, and enoxaparin, but the patient was more confused. An additional plasma exchange which was aimed at the immediate removal of autoantibody was performed with a good response. The symptoms rapidly disappeared except for the complex partial seizure which persisted until seven years post-SCT. Pediatr Blood Cancer 2011;57:153-156. (C) 2011 Wiley-Liss, Inc.

引用

页码：153 / 156

页数：4

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