Human umbilical cord-blood-derived mesenchymal stem cell can improve the clinical outcome and Joint space width after high tibial osteotomy

被引:7
作者
Suh, Dong Won [1 ]
Han, Seung Beom [1 ,2 ]
Yeo, Woo Jin [1 ]
Cheong, Kuhoang [1 ]
So, Sang-Yeon [1 ]
Kyung, Bong Soo [1 ]
机构
[1] Barunsesang Hosp, Joint Ctr, Seongnam, Gyeonggi Do, South Korea
[2] Korea Univ, Anam Hosp, Coll Med, Dept Orthoped Surg, Seoul, South Korea
关键词
Knee; Medial osteoarthritis; Cartilage defect; High tibial osteotomy; Umbilical cord-blood-derived mesenchymal stem cell; AUTOLOGOUS CHONDROCYTE IMPLANTATION; CARTILAGE REPAIR; KNEE; MICROFRACTURE; OSTEOARTHRITIS; AUGMENTATION; SURVIVAL;
D O I
10.1016/j.knee.2021.08.028
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Background: There is limited study about the human umbilical cord-blood derived mesenchymal stem cell (hUCB-MSC) cartilage regeneration procedures combined with high tibial osteotomy (HTO). We compared the clinical and radiological results of hUCB-MSC cartilage regeneration procedures combined with HTO to those of microfracture with HTO. Methods: From August 2017 to December 2018, HTO patients with International Cartilage Regeneration and Joint Preservation Society (ICRS) grade IV cartilage defects over 200 mm(2) on medial femoral condyle (MFC) were enrolled. For comparison, all participants were divided into two groups: those who had undergone an hUCB-MSC induced cartilage regeneration procedure (group MSC) and those with microfractures only (group C, controls). Clinically, Hospital for Special Surgery (HSS), International Knee Documentation Committee (IKDC), and Lysholm scores were evaluated post-operatively at 18 months. Radiologically, mechanical axis (MA) and joint space width (JSW) were evaluated. Results: A total of 100 knees were enrolled (43 in group MSC, 57 in group C). The IKDC score in group MSC (69) was better than that in group C (62; P < 0.05). The JSW increment in the MSC group (0.6 mm) was more than that in group C (0.1 mm; P < 0.05). No patient developed nonunion, correction loss, or arthroplasty conversion. Conclusion: hUCB-MSCs can improve clinical outcome and JSW better than microfracture only in HTO patients. (C) 2021 The Author(s). Published by Elsevier B.V.
引用
收藏
页码:31 / 37
页数:7
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