Radiotherapy in the Treatment of Hereditary Breast Cancer

被引:34
作者
Pierce, Lori J. [1 ]
Haffty, Bruce G. [2 ]
机构
[1] Univ Michigan, Ctr Comprehens Canc, Dept Radiat Oncol, Ann Arbor, MI 48109 USA
[2] UMDNJ, Robert Wood Johnson Med Sch, Canc Inst New Jersey, Dept Radiat Oncol, New Brunswick, NJ USA
关键词
BRCA1/2 MUTATION CARRIERS; BILATERAL PROPHYLACTIC MASTECTOMY; ATM GENE; ADJUVANT RADIOTHERAPY; CONSERVING TREATMENT; RISK; WOMEN; SUSCEPTIBILITY; POLYMORPHISMS; RECURRENCE;
D O I
10.1016/j.semradonc.2010.08.008
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Hereditary breast cancer represents approximately 5% to 10% of breast cancers and a larger portion of patients with early-onset disease. Given the relatively recent identification of the BRCA1 and BRCA2 genes, the available literature with respect to outcomes related to radiation therapy has inherent limitations with relatively small patient numbers and a lack of prospective randomized trials. There is, however, a growing body of literature describing treatment and toxicity outcomes in patients undergoing radiation therapy after breast-conserving surgery and after mastectomy for breast cancer patients who have BRCA1 and BRCA2 mutations. Acknowledging the limitations in the available data, there does not appear to be any evidence of more severe normal tissue reactions or compromised long-term survival rates in women electing breast-conserving surgery and radiation. These studies are reviewed in this article. Outcomes related to radiation therapy in patients with variants in other breast cancer related genes, such as p53, ATM, CHEK2, PALB2, and PTEN, are even less well documented because of the paucity of data. Available reports on radiation-related outcomes in these and single nucleotide polymorphisms in radiation repair and response genes are discussed. Semin Radiat Oncol 21:43-50 (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码:43 / 50
页数:8
相关论文
共 57 条
[1]   Survival in early-onset BRCA1 breast-cancer patients [J].
Ansquer, Y ;
Gautier, C ;
Fourquet, A ;
Asselain, B ;
Stoppa-Lyonnet, D .
LANCET, 1998, 352 (9127) :541-541
[2]   Radiation Exposure, the ATM Gene, and Contralateral Breast Cancer in the Women's Environmental Cancer and Radiation Epidemiology Study [J].
Bernstein, Jonine L. ;
Haile, Robert W. ;
Stovall, Marilyn ;
Boice, John D., Jr. ;
Shore, Roy E. ;
Langholz, Bryan ;
Thomas, Duncan C. ;
Bernstein, Leslie ;
Lynch, Charles F. ;
Olsen, Jorgen H. ;
Malone, Kathleen E. ;
Mellemkjaer, Lene ;
Borresen-Dale, Anne-Lise ;
Rosenstein, Barry S. ;
Teraoka, Sharon N. ;
Diep, Anh T. ;
Smith, Susan A. ;
Capanu, Marinela ;
Reiner, Anne S. ;
Liang, Xiaolin ;
Gatti, Richard A. ;
Concannon, Patrick .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2010, 102 (07) :475-483
[3]  
Breast Canc Linkage Consortium, 1999, JNCI-J NATL CANCER I, V91, P1310
[4]   Clinical radiosensitivity in breast cancer patients carrying pathogenic ATM gene mutations: no observation of increased radiation-induced acute, or late effects [J].
Bremer, M ;
Klopper, K ;
Yamini, P ;
Bendix-Waltes, R ;
Dork, T ;
Karstens, JH .
RADIOTHERAPY AND ONCOLOGY, 2003, 69 (02) :155-160
[5]   Excess risk for contralateral breast cancer in CHEK2*1100delC germline mutation carriers [J].
Broeks, A ;
de Witte, L ;
Nooijen, A ;
Huseinovic, A ;
Klijn, JGM ;
van Leeuwen, FE ;
Russell, NS ;
van't Veer, LJ .
BREAST CANCER RESEARCH AND TREATMENT, 2004, 83 (01) :91-93
[6]  
Brose MS, 2002, J NATL CANCER I, V94, P1365, DOI 10.1093/jnci/94.18.1365
[7]   Familial breast cancer: An investigation into the outcome of treatment for early stage disease [J].
Eccles D. ;
Simmonds P. ;
Goddard J. ;
Coultas M. ;
Hodgson S. ;
Lalloo F. ;
Evans G. ;
Haites N. .
Familial Cancer, 2001, 1 (2) :65-72
[8]   Linkage disequilibrium pattern of the ATM gene in breast cancer patients and controls; association of SNPs and haplotypes to radio-sensitivity and post-lumpectomy local recurrence [J].
Edvardsen, Hege ;
Tefre, Toril ;
Jansen, Laila ;
Vu, Phuong ;
Haffty, Bruce G. ;
Fossa, Sophie D. ;
Kristensen, Vessela N. ;
Borresen-Dale, Anne-Lise .
RADIATION ONCOLOGY, 2007, 2
[9]   Survival and recurrence after breast cancer in BRCA1/2 mutation carriers [J].
El-Tamer, M ;
Russo, D ;
Troxel, A ;
Bernardino, LP ;
Mazziotta, R ;
Estabrook, A ;
Ditkoff, BA ;
Schnabel, F ;
Mansukhani, M .
ANNALS OF SURGICAL ONCOLOGY, 2004, 11 (02) :157-164
[10]   Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families [J].
Ford, D ;
Easton, DF ;
Stratton, M ;
Narod, S ;
Goldgar, D ;
Devilee, P ;
Bishop, DT ;
Weber, B ;
Lenoir, G ;
Chang-Claude, J ;
Sobol, H ;
Teare, MD ;
Struewing, J ;
Arason, A ;
Scherneck, S ;
Peto, J ;
Rebbeck, TR ;
Tonin, P ;
Neuhausen, S ;
Barkardottir, R ;
Eyfjord, J ;
Lynch, H ;
Ponder, BAJ ;
Gayther, SA ;
Birch, JM ;
Lindblom, A ;
Stoppa-Lyonnet, D ;
Bignon, Y ;
Borg, A ;
Hamann, U ;
Haites, N ;
Scott, RJ ;
Maugard, CM ;
Vasen, H .
AMERICAN JOURNAL OF HUMAN GENETICS, 1998, 62 (03) :676-689