Synthesis and spectroscopy of near infrared fluorescent dyes for investigating dichromic fluorescence

被引：8

作者：

Bai, Mingfeng ^{[1
]}

Achilefu, Samuel ^{[1
,2
]}

机构：

[1] Washington Univ, Dept Radiol, St Louis, MO 63110 USA

[2] Washington Univ, Dept Biomed Engn, St Louis, MO 63110 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 01期

基金：

美国国家卫生研究院;

关键词：

NIR; Cyanine dye; Contrast agent; Optical imaging; Dual fluorescence; TRANSLOCATOR PROTEIN LIGAND; IN-VIVO CHARACTERIZATION; CONTRAST AGENTS; PROBES;

D O I：

10.1016/j.bmcl.2010.11.024

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We developed a series of near infrared (NIR) cyanine dyes to study dichromic fluorescence phenomenon, which provides new protocols for in vivo optical imaging. Preliminary spectroscopic studies show that dichromic fluorescence correlates with structural symmetry. This feature suggests the potential use of dichromic fluorescent molecules to study biological processes that can alter the structural symmetry of the molecular probes. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：280 / 284

页数：5

共 22 条

[1] Novel receptor-targeted fluorescent contrast agents for in vivo tumor imaging [J].

Achilefu, S ;

Dorshow, RB ;

Bugaj, JE ;

Rajagopalan, R .

INVESTIGATIVE RADIOLOGY, 2000, 35 (08) :479-485

[2] Self-assembled "dock and lock" system for linking payloads to targeting proteins [J].

Backer, Marina V. ;

Patel, Vimal ;

Jehning, Brian T. ;

Backer, Joseph M. .

BIOCONJUGATE CHEMISTRY, 2006, 17 (04) :912-919

[3] A novel functional translocator protein ligand for cancer imaging [J].

Bai, Mingfeng ;

Rone, Malena B. ;

Papadopoulos, Vassilios ;

Bornhop, Darryl J. .

BIOCONJUGATE CHEMISTRY, 2007, 18 (06) :2018-2023

[4] A novel conjugable translocator protein ligand labeled with a fluorescence dye for in vitro imaging [J].

Bai, Mingfeng ;

Wyatt, Shelby K. ;

Han, Zeqiu ;

Papadopoulos, Vassilios ;

Bornhop, Darryl J. .

BIOCONJUGATE CHEMISTRY, 2007, 18 (04) :1118-1122

[5]

Bloch S., 2005, Journal of Biomedical Optics, P10

[6] A primer on molecular biology for imagers: VII. Molecular imaging probes [J].

Danthi, SN ;

Pandit, SD ;

Li, KCP .

ACADEMIC RADIOLOGY, 2004, 11 (09) :1047-1054

[7] Imaging proteins in vivo using fluorescence lifetime microscopy [J].

Festy, Frederic ;

Ameer-Beg, Simon M. ;

Ng, Tony ;

Suhling, Klaus .

MOLECULAR BIOSYSTEMS, 2007, 3 (06) :381-391

[8] An enzymatically activated fluorescence probe for targeted tumor imaging [J].

Kamiya, Mako ;

Kobayashi, Hisataka ;

Hama, Yukihiro ;

Koyama, Yoshinori ;

Bernardo, Marcelino ;

Nagano, Tetsuo ;

Choyke, Peter L. ;

Urano, Yasuteru .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (13) :3918-3929

[9] Near-infrared fluorescent probes for imaging vascular pathophysiology [J].

Klohs, Jan ;

Wunder, Andreas ;

Licha, Kai .

BASIC RESEARCH IN CARDIOLOGY, 2008, 103 (02) :144-151

[10] Purification method directly influences effectiveness of an epidermal growth factor-coupled targeting agent for noninvasive tumor detection in mice [J].

Kovar, Joy L. ;

Volcheck, William M. ;

Chen, Jiyan ;

Simpson, Melanie A. .

ANALYTICAL BIOCHEMISTRY, 2007, 361 (01) :47-54

← 1 2 3 →