An ecotoxicological view on neurotoxicity assessment

被引：191

作者：

Legradi, J. B. ^{[1
,2
]}

Di Paolo, C. ^{[1
]}

Kraak, M. H. S. ^{[3
]}

van der Geest, H. G. ^{[3
]}

Schymanski, E. L. ^{[4
]}

Williams, A. J. ^{[5
]}

Dingemans, M. M. L. ^{[6
]}

Massei, R. ^{[7
]}

Brack, W. ^{[7
]}

Cousin, X. ^{[8
,9
]}

Begout, M. -L. ^{[10
]}

van der Oost, R. ^{[11
]}

Carion, A. ^{[12
]}

Suarez-Ulloa, V. ^{[12
]}

Silvestre, F. ^{[12
]}

Escher, B. I. ^{[13
,14
]}

Engwall, M. ^{[15
]}

Nilen, G. ^{[15
]}

Keiter, S. H. ^{[15
]}

Pollet, D. ^{[16
]}

Waldmann, P. ^{[16
]}

Kienle, C. ^{[17
]}

Werner, I. ^{[17
]}

Haigis, A. -C. ^{[1
]}

Knapen, D. ^{[18
]}

Vergauwen, L. ^{[18
]}

Spehr, M. ^{[19
]}

Schulz, W. ^{[20
]}

Busch, W. ^{[21
]}

Leuthold, D. ^{[21
]}

Scholz, S. ^{[21
]}

vom Berg, C. M. ^{[22
]}

Basu, N. ^{[23
]}

Murphy, C. A. ^{[24
]}

Lampert, A. ^{[25
]}

Kuckelkorn, J. ^{[26
]}

Grummt, T. ^{[26
]}

Hollert, H. ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Environm Res, Dept Ecosyst Anal, ABBt Aachen Biol & Biotechnol, Worringerweg 1, D-52074 Aachen, Germany

[2] Vrije Univ Amsterdam, Environm & Hlth, NL-1081 HV Amsterdam, Netherlands

[3] Univ Amsterdam, FAME Freshwater & Marine Ecol, Inst Biodivers & Ecosyst Dynam, POB 94248, NL-1090 GE Amsterdam, Netherlands

[4] Univ Luxembourg, LCSB, 6 Ave Swing, L-4367 Belvaux, Luxembourg

[5] US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA

[6] KWR Watercycle Res Inst, Groningenhaven 7, NL-3433 PE Nieuwegein, Netherlands

[7] UFZ Helmholtz Ctr Environm Res, Dept Effect Directed Anal, Permoserstr 15, Leipzig, Germany

[8] IFREMER, UMR MARBEC, Lab Adaptat & Adaptabilites Anim & Syst, Route Maguelone, F-34250 Palavas Les Flots, France

[9] AgroParisTech, INRA, UMR GABI, INRA, Batiment 231, F-78350 Jouy En Josas, France

[10] IFREMER, Lab Ressources Halieut, Pl Gaby Coll, F-17137 Lhoumeau, France

[11] Waternet Inst Urban Water Cycle, Dept Technol Res & Engn, Amsterdam, Netherlands

[12] Univ Namur, Lab Evolutionary & Adapt Physiol, Inst Life Earth & Environm, B-5000 Namur, Belgium

[13] UFZ Helmholtz Ctr Environm Res, Dept Cell Toxicol, Permoserstr 15, D-04318 Leipzig, Germany

[14] Eberhard Karls Univ Tubingen, Environm Toxicol, Ctr Appl Geosci, D-72074 Tubingen, Germany

[15] Orebro Univ, MTM Res Ctr, Sch Sci & Technol, Fak Gatan 1, S-70182 Orebro, Sweden

[16] Univ Appl Sci Darmstadt, Fac Chem Engn & Biotechnol, Stephanstr 7, D-64295 Darmstadt, Germany

[17] Swiss Ctr Appl Ecotoxicol Eawag EPFL, Uberlandstr 133, CH-8600 Dubendorf, Switzerland

[18] Univ Antwerp, Zebrafishlab, Vet Physiol & Biochem, Antwerp, Belgium

[19] Rhein Westfal TH Aachen, Inst Biol 2, Dept Chemosensat, Aachen, Germany

[20] Zweckverband Landeswasserversorgung, Langenau, Germany

[21] UFZ Helmholtz Ctr Environm Res, Dept Bioanalyt Ecotoxicol, Leipzig, Germany

[22] Eawag, Dept Environm Toxicol, Swiss Fed Inst Aquat Sci & Technol, CH-8600 Dubendorf, Switzerland

[23] McGill Univ, Fac Agr & Environm Sci, Montreal, PQ, Canada

[24] Michigan State Univ, Dept Fisheries & Wildlife, E Lansing, MI 48824 USA

[25] Inst Physiol Neurophysiol, Aachen, Germany

[26] Fed Environm Agcy UBA, Sect Toxicol Drinking Water & Swimming Pool Water, Heinrich Heine Str 12, D-08645 Bad Elster, Germany

来源：

ENVIRONMENTAL SCIENCES EUROPE | 2018年 / 30卷

关键词：

Eco-neurotoxicity; Neurotoxicity; EDA; REACH; AOP; Behaviour; Computational toxicity; Ecological; Species; EFFECT-DIRECTED ANALYSIS; ZEBRAFISH DANIO-RERIO; ADVERSE OUTCOME PATHWAYS; ENVIRONMENTAL RISK-ASSESSMENT; PERFORMANCE LIQUID-CHROMATOGRAPHY; PLURIPOTENT STEM-CELLS; DEVELOPMENTAL NEUROTOXICITY; DIESEL EXHAUST; LATERAL-LINE; ACETYLCHOLINESTERASE INHIBITORS;

D O I：

10.1186/s12302-018-0173-x

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The numbers of potential neurotoxicants in the environment are raising and pose a great risk for humans and the environment. Currently neurotoxicity assessment is mostly performed to predict and prevent harm to human populations. Despite all the efforts invested in the last years in developing novel in vitro or in silico test systems, in vivo tests with rodents are still the only accepted test for neurotoxicity risk assessment in Europe. Despite an increasing number of reports of species showing altered behaviour, neurotoxicity assessment for species in the environment is not required and therefore mostly not performed. Considering the increasing numbers of environmental contaminants with potential neurotoxic potential, eco-neurotoxicity should be also considered in risk assessment. In order to do so novel test systems are needed that can cope with species differences within ecosystems. In the field, online-biomonitoring systems using behavioural information could be used to detect neurotoxic effects and effect-directed analyses could be applied to identify the neurotoxicants causing the effect. Additionally, toxic pressure calculations in combination with mixture modelling could use environmental chemical monitoring data to predict adverse effects and prioritize pollutants for laboratory testing. Cheminformatics based on computational toxicological data from in vitro and in vivo studies could help to identify potential neurotoxicants. An array of in vitro assays covering different modes of action could be applied to screen compounds for neurotoxicity. The selection of in vitro assays could be guided by AOPs relevant for eco-neurotoxicity. In order to be able to perform risk assessment for eco-neurotoxicity, methods need to focus on the most sensitive species in an ecosystem. A test battery using species from different trophic levels might be the best approach. To implement eco-neurotoxicity assessment into European risk assessment, cheminformatics and in vitro screening tests could be used as first approach to identify eco-neurotoxic pollutants. In a second step, a small species test battery could be applied to assess the risks of ecosystems.

引用

页数：34

共 330 条

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