Clinical impact of comprehensive geriatric assessment in patients aged 80 years and older with diffuse large B-cell lymphoma receiving rituximab-mini-CHOP: a single-institute retrospective study

被引：6

作者：

Yamasaki, Satoshi ^{[1
,2
]}

Matsushima, Takumi ^{[1
]}

Minami, Mariko ^{[1
]}

Kadowaki, Masanori ^{[1
]}

Takase, Ken ^{[1
]}

Iwasaki, Hiromi ^{[1
]}

机构：

[1] Natl Hosp Org Kyushu Med Ctr, Clin Res Inst, Dept Hematol, Fukuoka, Japan

[2] Kyushu Univ, Dept Internal Med, Beppu Hosp, Tsurumi Ku, 4546 Tsurumihara, Beppu, Oita 8740838, Japan

来源：

EUROPEAN GERIATRIC MEDICINE | 2022年 / 13卷 / 01期

关键词：

Diffuse large B-cell lymphoma; Elderly patients; Comprehensive geriatric assessment; Instrumental activities of daily living; ELDERLY-PATIENTS; UNITED-STATES; MULTICENTER; CLASSIFICATION; ARM;

D O I：

10.1007/s41999-021-00539-8

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Key summary pointsAim To investigate comprehensive geriatric assessment (CGA), we examined previously reported risk factors associated with outcomes among patients aged 80 years and older with diffuse large B-cell lymphoma (DLBCL) to identify individuals suitable for novel therapies. Findings Instrumental activities of daily living < 5 and > 85 years old were risk factors for poor overall survival among 142 patients aged 80 years and older with DLBCL who received R-mini-CHOP at 4-week intervals. Message Strategies that carefully select elderly patients aged 80 years and older with DLBCL using CGA may help to identify individuals suitable for novel therapies. Purpose Comprehensive geriatric assessment (CGA) has been used to help identify elderly patients with diffuse large B-cell lymphoma (DLBCL) who were suitable for rituximab combined with CHOP therapy (cyclophosphamide, Adriamycin, vincristine, and prednisolone), but there are few reports of CGA for elderly patients with DLBCL who received R-mini-CHOP. Methods We retrospectively analyzed the risk factors for outcomes among 142 patients aged 80 years and older (<= 85 years, n = 102; > 85 years, n = 40) with DLBCL who received R-mini-CHOP at 4-week intervals at our institute between 2008 and 2019. We performed a comparison between CGA and treatment outcomes. Results There were significant differences in progression-free survival between patients with international prognostic index (IPI) scores of > 3 and <= 3 at diagnosis and in overall survival between patients with instrumental activities of daily living (IADL) scores of >= 5 and IADL < 5 before the initial treatment and patients aged <= 85 years and > 85 years. Conclusion Strategies that carefully select elderly patients aged 80 years and older with DLBCL using CGA may help to identify individuals suitable for novel therapies.

引用

页码：195 / 201

页数：7

共 23 条

[11] ASSESSMENT OF OLDER PEOPLE - SELF-MAINTAINING AND INSTRUMENTAL ACTIVITIES OF DAILY LIVING [J].

LAWTON, MP ;

BRODY, EM .

GERONTOLOGIST, 1969, 9 (3P1) :179-&

[12] Impact of relative dose intensity of standard regimens on survival in elderly patients aged 80 years and older with diffuse large B-cell lymphoma [J].

Lee, Shin ;

Fujita, Kei ;

Negoro, Eiju ;

Morishita, Tetsuji ;

Oiwa, Kana ;

Tsukasaki, Hikaru ;

Kinoshita, Keiichi ;

Kawai, Yasukazu ;

Ueda, Takanori ;

Yamauchi, Takahiro .

HAEMATOLOGICA, 2020, 105 (08) :E415-E418

[13] Prognostic value of the G8 and modified-G8 screening tools for multidimensional health problems in older patients with cancer [J].

Martinez-Tapia, Claudia ;

Paillaud, Elena ;

Liuu, Evelyne ;

Tournigand, Christophe ;

Ibrahim, Rima ;

Fossey-Diaz, Virginie ;

Culine, Stephane ;

Canoui-Poitrine, Florence ;

Audureau, Etienne .

EUROPEAN JOURNAL OF CANCER, 2017, 83 :211-219

[14] Geriatric Research Policy: Japan Clinical Oncology Group (JCOG) policy [J].

Mizutani, Tomonori ;

Nakamura, Kenichi ;

Fukuda, Haruhiko ;

Ogawa, Asao ;

Hamaguchi, Tetsuya ;

Nagashima, Fumio .

JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2019, 49 (10) :901-909

[15] Practical Assessment and Management of Vulnerabilities in Older Patients Receiving Chemotherapy: ASCO Guideline for Geriatric Oncology [J].

Mohile, Supriya G. ;

Dale, William ;

Somerfield, Mark R. ;

Schonberg, Mara A. ;

Boyd, Cynthia M. ;

Burhenn, Peggy S. ;

Canin, Beverly ;

Cohen, Harvey Jay ;

Holmes, Holly M. ;

Hopkins, Judith O. ;

Janelsins, Michelle C. ;

Khorana, Alok A. ;

Klepin, Heidi D. ;

Lichtman, Stuart M. ;

Mustian, Karen M. ;

Tew, William P. ;

Hurria, Arti .

JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (22) :2326-+

[16] Lymphorna incidence patterns by WHO subtype in the United States, 1992-2001 [J].

Morton, LM ;

Wang, SS ;

Devesa, SS ;

Hartge, P ;

Weisenburger, DD ;

Linet, MS .

BLOOD, 2006, 107 (01) :265-276

[17] Comprehensive geriatric assessment is useful in an elderly Australian population with diffuse large B-cell lymphoma receiving rituximab-chemotherapy combinations [J].

Ong, Doen Ming ;

Ashby, Michael ;

Grigg, Andrew ;

Gard, Grace ;

Ng, Zi Y. ;

Huang, Huayi ;

Chong, Yee Shuen ;

Cheah, Chan Yoon ;

Devitt, Bianca ;

Chong, Geoffrey ;

Loh, Zoe ;

Mo, Allison ;

Hawkes, Eliza A. .

BRITISH JOURNAL OF HAEMATOLOGY, 2019, 187 (01) :73-81

[18] Combination of ofatumumab and reduced-dose CHOP for diffuse large B-cell lymphomas in patients aged 80 years or older: an open-label, multicentre, single-arm, phase 2 trial from the LYSA group [J].

Peyrade, Frederic ;

Bologna, Serge ;

Delwail, Vincent ;

Emile, Jean Francois ;

Pascal, Laurent ;

Ferme, Christophe ;

Schiano, Jean-Marc ;

Coiffier, Bertrand ;

Corront, Bernadette ;

Farhat, Hassan ;

Fruchart, Christophe ;

Ghesquieres, Herve ;

Macro, Margaret ;

Tilly, Herve ;

Choufi, Bachra ;

Delarue, Richard ;

Fitoussi, Olivier ;

Gabarre, Jean ;

Haioun, Corinne ;

Jardin, Fabrice .

LANCET HAEMATOLOGY, 2017, 4 (01) :E46-E55

[19] Attenuated immunochemotherapy regimen (R-miniCHOP) in elderly patients older than 80 years with diffuse large B-cell lymphoma: a multicentre, single-arm, phase 2 trial [J].

Peyrade, Frederic ;

Jardin, Fabrice ;

Thieblemont, Catherine ;

Thyss, Antoine ;

Emile, Jean-Francois ;

Castaigne, Sylvie ;

Coiffier, Bertrand ;

Haioun, Corinne ;

Bologna, Serge ;

Fitoussi, Olivier ;

Lepeu, Gerard ;

Fruchart, Christophe ;

Bordessoule, Dominique ;

Blanc, Michel ;

Delarue, Richard ;

Janvier, Maud ;

Salles, Bruno ;

Andre, Marc ;

Fournier, Marion ;

Gaulard, Philippe ;

Tilly, Herve .

LANCET ONCOLOGY, 2011, 12 (05) :460-468

[20] The 2016 revision of the World Health Organization classification of lymphoid neoplasms [J].

Swerdlow, Steven H. ;

Campo, Elias ;

Pileri, Stefano A. ;

Harris, Nancy Lee ;

Stein, Harald ;

Siebert, Reiner ;

Advani, Ranjana ;

Ghielmini, Michele ;

Salles, Gilles A. ;

Zelenetz, Andrew D. ;

Jaffe, Elaine S. .

BLOOD, 2016, 127 (20) :2375-2390

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