Clinical impact of comprehensive geriatric assessment in patients aged 80 years and older with diffuse large B-cell lymphoma receiving rituximab-mini-CHOP: a single-institute retrospective study

Key summary pointsAim To investigate comprehensive geriatric assessment (CGA), we examined previously reported risk factors associated with outcomes among patients aged 80 years and older with diffuse large B-cell lymphoma (DLBCL) to identify individuals suitable for novel therapies. Findings Instrumental activities of daily living < 5 and > 85 years old were risk factors for poor overall survival among 142 patients aged 80 years and older with DLBCL who received R-mini-CHOP at 4-week intervals. Message Strategies that carefully select elderly patients aged 80 years and older with DLBCL using CGA may help to identify individuals suitable for novel therapies. Purpose Comprehensive geriatric assessment (CGA) has been used to help identify elderly patients with diffuse large B-cell lymphoma (DLBCL) who were suitable for rituximab combined with CHOP therapy (cyclophosphamide, Adriamycin, vincristine, and prednisolone), but there are few reports of CGA for elderly patients with DLBCL who received R-mini-CHOP. Methods We retrospectively analyzed the risk factors for outcomes among 142 patients aged 80 years and older (<= 85 years, n = 102; > 85 years, n = 40) with DLBCL who received R-mini-CHOP at 4-week intervals at our institute between 2008 and 2019. We performed a comparison between CGA and treatment outcomes. Results There were significant differences in progression-free survival between patients with international prognostic index (IPI) scores of > 3 and <= 3 at diagnosis and in overall survival between patients with instrumental activities of daily living (IADL) scores of >= 5 and IADL < 5 before the initial treatment and patients aged <= 85 years and > 85 years. Conclusion Strategies that carefully select elderly patients aged 80 years and older with DLBCL using CGA may help to identify individuals suitable for novel therapies.