Mechanisms of B-cell lymphoma pathogenesis

被引：660

作者：

Küppers, R ^{[1
]}

机构：

[1] Univ Duisburg Essen, Sch Med, Inst Cell Biol Tumor Res, D-45122 Essen, Germany

来源：

NATURE REVIEWS CANCER | 2005年 / 5卷 / 04期

关键词：

D O I：

10.1038/nrc1589

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chromosomal translocations involving the immunoglobulin loci are a hallmark of many types of B-cell lymphoma. Other factors, however, also have important roles in the pathogenesis of B-cell malignancies. Most B-cell lymphomas depend on the expression of a B-cell receptor (BCR) for survival, and in several B-cell malignancies antigen activation of lymphoma cells through BCR signalling seems to be an important factor for lymphoma pathogenesis. Recent insights into the lymphomagenic role of factors supplied by the microenvironment also offer new therapeutic strategies.

引用

收藏

页码：251 / 262

页数：12

相关论文

共 152 条

[1] Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling [J].

Alizadeh, AA ;

Eisen, MB ;

Davis, RE ;

Ma, C ;

Lossos, IS ;

Rosenwald, A ;

Boldrick, JG ;

Sabet, H ;

Tran, T ;

Yu, X ;

Powell, JI ;

Yang, LM ;

Marti, GE ;

Moore, T ;

Hudson, J ;

Lu, LS ;

Lewis, DB ;

Tibshirani, R ;

Sherlock, G ;

Chan, WC ;

Greiner, TC ;

Weisenburger, DD ;

Armitage, JO ;

Warnke, R ;

Levy, R ;

Wilson, W ;

Grever, MR ;

Byrd, JC ;

Botstein, D ;

Brown, PO ;

Staudt, LM .

NATURE, 2000, 403 (6769) :503-511

[2] Disruption of the B-cell specific transcriptional program in HHV-8 associated primary effusion lymphoma cell lines [J].

Arguello, M ;

Sgarbanti, M ;

Hernandez, E ;

Mamane, Y ;

Sharma, S ;

Servant, M ;

Lin, RT ;

Hiscott, J .

ONCOGENE, 2003, 22 (07) :964-973

[3]

Avet-Loiseau H, 1998, CANCER RES, V58, P5640

[4] CLONAL EVOLUTION OF A FOLLICULAR LYMPHOMA - EVIDENCE FOR ANTIGEN SELECTION [J].

BAHLER, DW ;

LEVY, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (15) :6770-6774

[5] IDENTIFICATION OF THE GENE ASSOCIATED WITH THE RECURRING CHROMOSOMAL TRANSLOCATIONS T(3,14)(Q27,Q32) AND T(3,22)(Q27,Q11) IN B-CELL LYMPHOMAS [J].

BARON, BW ;

NUCIFORA, G ;

MCCABE, N ;

ESPINOSA, R ;

LEBEAU, MM ;

MCKEITHAN, TW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (11) :5262-5266

[6]

BENDE RJ, IN PRESS J EXP MED, V201

[7] Lack of CD95/FAS gene somatic mutations in extranodal, nodal and splenic marginal zone B cell lymphomas [J].

Bertoni, F ;

Conconi, A ;

Luminari, S ;

Realini, C ;

Roggero, E ;

Baldini, L ;

Carobbio, S ;

Cavalli, F ;

Neri, A ;

Zucca, E .

LEUKEMIA, 2000, 14 (03) :446-448

[8]

BORCHE L, 1990, BLOOD, V76, P562

[9] Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin disease, represent clonal populations of germinal center-derived tumor B cells [J].

Braeuninger, A ;

Kuppers, R ;

Strickler, JG ;

Wacker, HH ;

Rajewsky, K ;

Hansmann, ML .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (17) :9337-9342

[10] Epstein-Barr virus (EBV)-positive lymphoproliferations in post-transplant patients show immunoglobulin V gene mutation patterns suggesting interference of EBV with normal B cell differentiation processes [J].

Bräuninger, A ;

Spieker, T ;

Mottok, A ;

Baur, AS ;

Kuppers, R ;

Hansmann, ML .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2003, 33 (06) :1593-1602

← 1 2 3 4 5 6 7 8 9 10 →