Stimulated neuronal expression of brain-derived neurotrophic factor by Neurotropin

被引：50

作者：

Fukuda, Yu ^{[1
,2
,3
,6
]}

Berry, Thomas L. ^{[2
,3
]}

Nelson, Matthew ^{[4
]}

Hunter, Christopher L. ^{[4
]}

Fukuhara, Koki ^{[2
,3
,5
,6
]}

Imai, Hideki ^{[6
]}

Ito, Shinji ^{[1
]}

Granholm-Bentley, Ann-Charlotte ^{[4
]}

Kaplan, Allen P. ^{[2
,3
]}

Mutoh, Tatsuro ^{[1
]}

机构：

[1] Fajita Hlth Univ, Sch Med, Dept Neurol, Toyoake, Aichi 4701192, Japan

[2] Med Univ S Carolina, Konishi MUSC Inst Inflammat Res, Charleston, SC 29425 USA

[3] Med Univ S Carolina, Dept Med, Div Pulm & Crit Care Med Allergy & Clin Immunol, Charleston, SC 29425 USA

[4] Med Univ S Carolina, Dept Neurosci, Ctr Aging, Charleston, SC 29425 USA

[5] NINR, NIH, Bethesda, MD 20892 USA

[6] Nippon Zoki Pharmaceut Co Ltd, Chuo Ku, Osaka 5410046, Japan

来源：

MOLECULAR AND CELLULAR NEUROSCIENCE | 2010年 / 45卷 / 03期

关键词：

Neurotropin; Brain-derived neurotrophic factor; CREB pathway; TrkB; Ts65Dn mice; Down's syndrome; Radial-arm maze; NERVE GROWTH-FACTOR; ADULT HIPPOCAMPAL NEUROGENESIS; AMYLOID PRECURSOR PROTEIN; SPINAL DORSAL-HORN; GENE-EXPRESSION; MOUSE MODEL; WORKING-MEMORY; DOWNS-SYNDROME; CNS DISORDERS; CHRONIC PAIN;

D O I：

10.1016/j.mcn.2010.06.013

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Expression of brain-derived neurotrophic factor (BDNF) was stimulated in human neuroblastoma SH-SY5Y cells by a nonprotein extract of inflamed rabbit skin inoculated with vaccinia virus (Neurotropin (R)), an analgesic widely used in Japan for treatment of disorders associated with chronic pain, with the optimal dosage at 10 mNU/mL This stimulation was accompanied by activations of p42/44 MAP kinase, CREB and c-Fos expression. Inhibitors of MAP kinases or PI 3-kinase prevented the stimulatory action of Neurotropin, indicating that neuronal TrkB/CREB pathway mediates the action. Repetitive oral administration of Neurotropin (200 NU/kg/day, 3 months) prevented the age-dependent decline in hippocampal BDNF expression in Ts65Dn mice, a model of Down's syndrome. This effect was associated with the improvement of spatial cognition of the mice. These results open an intriguing new strategy in which Neurotropin may prove beneficial treatment for neurodegenerative disorders. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：226 / 233

页数：8

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