The voltage-dependent K+ channels Kv1.3 and Kv1.5 in human cancer

被引：108

作者：

Comes, Nuria ^{[1
]}

Bielanska, Joanna ^{[1
]}

Vallejo-Gracia, Albert ^{[1
]}

Serrano-Albarras, Antonio ^{[1
]}

Marruecos, Laura ^{[2
]}

Gomez, Diana ^{[2
]}

Soler, Concepcio ^{[2
]}

Condom, Enric ^{[2
]}

Ramon y Cajal, Santiago ^{[2
,3
]}

Hernandez-Losa, Javier ^{[3
]}

Ferreres, Joan C. ^{[3
]}

Felipe, Antonio ^{[1
]}

机构：

[1] Univ Barcelona, Mol Physiol Lab, Dept Bioquim & Biol Mol, Inst Biomed, E-08028 Barcelona, Spain

[2] Hosp Univ Bellvitge IDIBELL, Dept Patol & Terapeut Expt, Barcelona, Spain

[3] Univ Autonoma Barcelona, Hosp Univ Vall dHebron, Dept Anat Patol, E-08193 Barcelona, Spain

来源：

FRONTIERS IN PHYSIOLOGY | 2013年 / 4卷

关键词：

K+ channels; cancer; agressiveness; tumor markers; proliferation; GATED POTASSIUM CHANNELS; HUMAN PROSTATE-CANCER; VERAPAMIL INHIBITS PROLIFERATION; SMOOTH-MUSCLE-CELLS; HUMAN T-LYMPHOCYTES; ION CHANNELS; GROWTH-FACTOR; DIFFERENTIAL EXPRESSION; DELAYED RECTIFIER; SKELETAL-MUSCLE;

D O I：

10.3389/fphys.2013.00283

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Voltage-dependent K+ channels (Kv) are involved in a number of physiological processes, including immunomodulation, cell volume regulation, apoptosis as well as differentiation. Some Kv channels participate in the proliferation and migration of normal and tumor cells, contributing to metastasis. Altered expression of Kv1.3 and Kv1.5 channels has been found in several types of tumors and cancer cells. In general, while the expression of Kv1.3 apparently exhibits no clear pattern, Kv1.5 is induced in many of the analyzed metastatic tissues. Interestingly, evidence indicates that Kv1.5 channel shows inversed correlation with malignancy in some gliomas and non-Hodgkin's lymphomas. However, Kv1.3 and Kv1.5 are similarly remodeled in some cancers. For instance, expression of Kv1.3 and Kv1.5 correlates with a certain grade of tumorigenicity in muscle sarcomas. Differential remodeling of Kv1.3 and Kv1.5 expression in human cancers may indicate their role in tumor growth and their importance as potential tumor markers. However, despite of this increasing body of information, which considers Kv1.3 and Kv1.5 as emerging tumoral markers, further research must be performed to reach any conclusion. In this review, we summarize what it has been lately documented about Kv1.3 and Kv1.5 channels in human cancer.

引用

页数：13

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