The lipid connection-regulation of voltage-gated Ca2+ channels by phosphoinositides

被引：38

作者：

Michailidis, Ioannis E. ^{[1
]}

Zhang, Yun ^{[1
]}

Yang, Jian ^{[1
]}

机构：

[1] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2007年 / 455卷 / 01期

关键词：

calcium channel; phospholipid; regulation; GTP binding protein; signal transduction;

D O I：

10.1007/s00424-007-0272-9

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Recent findings have revealed a pivotal role for phospholipids phosphatidylinositol -4,5-biphosphate (PIP2) and phosphatidylinositol -3,4,5-trisphosphate (PIP3) in the regulation of high voltage-activated (HVA) Ca2+ channels. PIP2 exerts two opposing actions on HVA Ca2+ channels: It stabilizes their activity but also produces a voltage-dependent inhibition that can be antagonized by protein kinase A (PKA) phosphorylation. PIP2 depletion and arachidonic acid together mediate the slow, voltage-independent inhibition of HVA Ca2+ channels by G (q/11) -coupled receptors in neurons. A sufficient level of plasma membrane PIP2 also appears to be necessary for G (beta gamma) -mediated inhibition. On the other hand, increased production of PIP3 by PI-3 kinases promotes trafficking of HVA Ca2+ channels to the plasma membrane. This review discusses these findings and their implications.

引用

页码：147 / 155

页数：9

共 53 条

[1] Arachidonic acid reversibly enhances N-type calcium current at an extracellular site [J].

Barrett, CF ;

Liu, LW ;

Rittenhouse, AR .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2001, 280 (05) :C1306-C1318

[2] BETA-ADRENERGIC MODULATION OF CALCIUM CHANNELS IN FROG VENTRICULAR HEART-CELLS [J].

BEAN, BP ;

NOWYCKY, MC ;

TSIEN, RW .

NATURE, 1984, 307 (5949) :371-375

[3] NEUROTRANSMITTER INHIBITION OF NEURONAL CALCIUM CURRENTS BY CHANGES IN CHANNEL VOLTAGE DEPENDENCE [J].

BEAN, BP .

NATURE, 1989, 340 (6229) :153-156

[4] IGF-1 modulates N and L calcium channels in a PI 3-kinase-dependent manner [J].

Blair, LAC ;

Marshall, J .

NEURON, 1997, 19 (02) :421-429

[5]

BOLAND LM, 1993, J NEUROSCI, V13, P516

[6] The phosphoinositide 3-kinase pathway [J].

Cantley, LC .

SCIENCE, 2002, 296 (5573) :1655-1657

[7] Structure and regulation of voltage-gated Ca2+ channels [J].

Catterall, WA .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2000, 16 :521-555

[8]

Cremona O, 2001, J CELL SCI, V114, P1041

[9] Modular phosphoinositide-binding domains - their role in signalling and membrane trafficking [J].

Cullen, PJ ;

Cozier, GE ;

Banting, G ;

Mellor, H .

CURRENT BIOLOGY, 2001, 11 (21) :R882-R893

[10] Pathways modulating neural KCNQ/M (Kv7) potassium channels [J].

Delmas, P ;

Brown, DA .

NATURE REVIEWS NEUROSCIENCE, 2005, 6 (11) :850-862

← 1 2 3 4 5 6 →