The 10-year trajectories of auditory hallucinations among 496 patients with a first schizophrenia-spectrum disorder: Findings from the OPUS cohort

被引:5
作者
Kohler-Forsberg, Ole [1 ,2 ,3 ,6 ]
Madsen, Trine [1 ,4 ]
Behrendt-Moller, Ida [1 ,5 ]
Nordentoft, Merete [1 ,4 ,5 ]
机构
[1] Univ Copenhagen, Mental Hlth Ctr Copenhagen, CORE, Copenhagen, Denmark
[2] Aarhus Univ Hosp, Psychosis Res Unit, Psychiat, Aarhus, Denmark
[3] Aarhus Univ, Dept Clin Med, Aarhus, Denmark
[4] Danish Res Inst Suicide Prevent DRISP, Copenhagen, Denmark
[5] Univ Copenhagen, Fac Hlth Sci, Dept Clin Med, Copenhagen, Denmark
[6] Aarhus Univ Hosp, Psychosis Res Unit, Psychiat, Palle Juul Jensens Blvd 175, DK-8200 Aarhus, Denmark
关键词
Schizophrenia; Auditory hallucinations; Trajectories; Early intervention; First-episode psychosis; MULTI-FOLLOW-UP; PREMORBID ADJUSTMENT; STANDARD TREATMENT; NEGATIVE SYMPTOMS; SUICIDAL IDEATION; PSYCHOSIS; EPISODE; TRIAL;
D O I
10.1016/j.schres.2021.06.033
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background: Auditory hallucinations represent a key diagnostic feature of schizophrenia and one of the most frequent and debilitating psychotic symptoms. However, little is known regarding their long-term trajectories. Methods: We included 496 patients with a first schizophrenia-spectrum disorder. Patients were at baseline and after one, two, five, and ten years asked for auditory hallucinations, scoring from 0 ("None") to 5 ("Severe: Voices occur often every day"). We performed latent class growth analyses to identify trajectories of auditory hallucinations and multinomial logistic regression analyses to estimate predictors of trajectory membership.Results: We identified three trajectories of auditory hallucinations. The Low-Decreasing class (77%) had the lowest mean score at baseline (mean score = 2.1). The score improved within the first year (mean score = 0.5) and stayed low (mean score = 0 after ten years). The High-Fluctuating class (10%) improved during the first two years from a mean score of 3.0 to 1.0, but increased after five and ten years (mean score = 2.4). The High-Increasing class (13%) started at a high level (mean score = 3.5), improved a little after one year (mean score = 3.0), but increased to a mean score of 4.8 after ten years. Alcohol misuse and longer duration of untreated psychosis were associated with increased odds of being in the High-Increasing compared to the Low-Decreasing class.Conclusions: The majority of patients with schizophrenia-spectrum disorder improved on auditory hallucinations during the first ten years, but almost one out of four had a fluctuating course with 13% experiencing an increase to severe and daily auditory hallucinations after ten years.
引用
收藏
页码:385 / 391
页数:7
相关论文
共 32 条
  • [1] Global Assessment of Functioning (GAF): properties and frontier of current knowledge
    Aas, I. H. Monrad
    [J]. ANNALS OF GENERAL PSYCHIATRY, 2010, 9
  • [2] Trajectories of positive, negative and general psychopathology symptoms in first episode psychosis and their relationship with functioning over a 2-year follow-up period
    Abdin, Edimansyah
    Chong, Siow Ann
    Vaingankar, Janhavi Ajit
    Peh, Chao Xu
    Poon, Lye Yin
    Rao, Sujatha
    Verma, Swapna
    Subramaniam, Mythily
    [J]. PLOS ONE, 2017, 12 (11):
  • [3] ANDREASEN NC, 1990, ARCH GEN PSYCHIAT, V47, P615
  • [4] ANDREASEN NC, 1989, BRITISH JOURNAL OF PSYCHIATRY, VOL 155, SUPP NO. 7, P49
  • [5] [Anonymous], 1984, GROUP
  • [6] Auxiliary Variables in Mixture Modeling: Three-Step Approaches Using Mplus
    Asparouhov, Tihomir
    Muthen, Bengt
    [J]. STRUCTURAL EQUATION MODELING-A MULTIDISCIPLINARY JOURNAL, 2014, 21 (03) : 329 - 341
  • [7] Long-term trajectories of positive and negative symptoms in first episode psychosis: A 10 year follow-up study in the OPUS cohort
    Austin, Stephen F.
    Mors, Ole
    Budtz-Jorgensen, Esben
    Secher, Rikke Gry
    Hjorthoj, Carsten R.
    Bertelsen, Mette
    Jeppesen, Pia
    Petersen, Lone
    Thorup, Anne
    Nordentoft, Merete
    [J]. SCHIZOPHRENIA RESEARCH, 2015, 168 (1-2) : 84 - 91
  • [8] Diagnostic Shifts During the Decade Following First Admission for Psychosis
    Bromet, Evelyn J.
    Kotov, Roman
    Fochtmann, Laura J.
    Carlson, Gabrielle A.
    Tanenberg-Karant, Marsha
    Ruggero, Camilo
    Chang, Su-wei
    [J]. AMERICAN JOURNAL OF PSYCHIATRY, 2011, 168 (11) : 1186 - 1194
  • [9] MEASUREMENT OF PREMORBID ADJUSTMENT IN CHRONIC-SCHIZOPHRENIA
    CANNONSPOOR, HE
    POTKIN, SG
    WYATT, RJ
    [J]. SCHIZOPHRENIA BULLETIN, 1982, 8 (03) : 470 - 484
  • [10] Early-Stage Negative Symptom Trajectories and Relationships With 13-Year Outcomes in First-Episode Nonaffective Psychosis
    Chang, Wing Chung
    Ho, Ryan Wui Hang
    Tang, Jennifer Yee Man
    Wong, Corine Sau Man
    Hui, Christy Lai Ming
    Chan, Sherry K. W.
    Lee, Edwin M. H.
    Suen, Yi Nam
    Chen, Eric Y. H.
    [J]. SCHIZOPHRENIA BULLETIN, 2019, 45 (03) : 610 - 619