Addiction Research Consortium: Losing and regaining control over drug intake (ReCoDe)-From trajectories to mechanisms and interventions

被引：132

作者：

Heinz, Andreas ^{[1
]}

Kiefer, Falk ^{[2
]}

Smolka, Michael N. ^{[3
,4
]}

Endrass, Tanja ^{[5
]}

Beste, Christian ^{[6
]}

Beck, Anne ^{[1
]}

Liu, Shuyan ^{[1
]}

Genauck, Alexander ^{[1
]}

Romund, Lydia ^{[1
]}

Banaschewski, Tobias ^{[7
]}

Bermpohl, Felix ^{[1
]}

Deserno, Lorenz ^{[3
,4
,8
,9
]}

Dolan, Raymond J. ^{[8
,9
]}

Durstewitz, Daniel ^{[10
]}

Ebner-Priemer, Ulrich ^{[11
]}

Flor, Herta ^{[12
,13
]}

Hansson, Anita C. ^{[14
]}

Heim, Christine ^{[15
,16
]}

Hermann, Derik ^{[2
,17
]}

Kiebel, Stefan ^{[3
,4
,18
]}

Kirsch, Peter ^{[19
]}

Kirschbaum, Clemens ^{[20
]}

Koppe, Georgia ^{[10
]}

Marxen, Michael ^{[3
,4
]}

Meyer-Lindenberg, Andreas ^{[21
]}

Nagel, Wolfgang E. ^{[22
]}

Noori, Hamid R. ^{[14
,23
]}

Pilhatsch, Maximilian ^{[24
]}

Priller, Josef ^{[25
,26
,27
]}

Rietschel, Marcella ^{[28
]}

Romanczuk-Seiferth, Nina ^{[1
]}

Schlagenhauf, Florian ^{[1
]}

Sommer, Wolfgang H. ^{[2
,14
]}

Stallkamp, Jan ^{[29
]}

Stroehle, Andreas ^{[1
]}

Stock, Ann-Kathrin ^{[6
]}

Winterer, Georg ^{[30
]}

Winter, Christine ^{[1
]}

Walter, Henrik ^{[1
]}

Witt, Stephanie ^{[28
]}

Vollstaedt-Klein, Sabine ^{[2
]}

Rapp, Michael A. ^{[31
]}

Tost, Heike ^{[21
]}

Spanagel, Rainer ^{[14
]}

机构：

[1] Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Campus Charite Mitte, Charitepl 1, D-10117 Berlin, Germany

[2] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Addict Behav & Addict Med, Mannheim, Germany

[3] Tech Univ Dresden, Dept Psychiat, Dresden, Germany

[4] Tech Univ Dresden, Neuroimaging Ctr, Dresden, Germany

[5] Tech Univ Dresden, Inst Clin Psychol & Psychotherapy, Dresden, Germany

[6] Tech Univ Dresden, Dept Child & Adolescent Psychiat, Cognit Neurophysiol, Dresden, Germany

[7] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Child & Adolescent Psychiat & Psychotherapy, Mannheim, Germany

[8] UCL, Max Planck Ctr Computat Psychiat & Ageing Res, London, England

[9] UCL, Wellcome Ctr Human Neuroimaging, London, England

[10] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Theoret Neurosci, Mannheim, Germany

[11] Karlsruhe Inst Technol, Dept Sports & Sports Sci, Karlsruhe, Germany

[12] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Cognit & Clin Neurosci, Mannheim, Germany

[13] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Psychol,Sch Social Sci, Mannheim, Germany

[14] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Inst Psychopharmacol, J5 Mannheim, Mannheim, Germany

[15] Charite Univ Med Berlin, Inst Med Psychol, Berlin, Germany

[16] Penn State Univ, Dept Biobehav Hlth, University Pk, PA 16802 USA

[17] Heidelberg Univ, Feuerlein Ctr Translat Addict Med FCTS, Heidelberg, Germany

[18] Tech Univ Dresden, Dept Psychol, Dresden, Germany

[19] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Clin Psychol, Mannheim, Germany

[20] Tech Univ Dresden, Dept Psychol, Biol Psychol, Dresden, Germany

[21] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, Mannheim, Germany

[22] Tech Univ Dresden, Ctr Informat Serv & High Performance Comp, Dresden, Germany

[23] Max Planck Inst Biol Cybernet, Tubingen, Germany

[24] Tech Univ Dresden, Fac Med, Univ Hosp Carl Gustav Carus, Dept Psychiat & Psychotherapy, Dresden, Germany

[25] Charite Univ Med Berlin, Dept Neuropsychiat, Berlin, Germany

[26] Charite Univ Med Berlin, Lab Mol Psychiat, Berlin, Germany

[27] Univ Edinburgh, UK Dementia Res Inst, Edinburgh, Midlothian, Scotland

[28] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat, Mannheim, Germany

[29] Fraunhofer IPA, Project Grp Automat Med & Biotechnol, Mannheim, Germany

[30] Charite Univ Med Berlin, Dept Anesthesiol & Intens Care Med, ECRC, Berlin, Germany

[31] Univ Potsdam, Social & Prevent Med, Potsdam, Germany

来源：

ADDICTION BIOLOGY | 2020年 / 25卷 / 02期

关键词：

addiction; alternative rewards; animal and computational models; cognitive-behavioral control; craving and relapse; habit formation; ALCOHOL;

D O I：

10.1111/adb.12866

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

One of the major risk factors for global death and disability is alcohol, tobacco, and illicit drug use. While there is increasing knowledge with respect to individual factors promoting the initiation and maintenance of substance use disorders (SUDs), disease trajectories involved in losing and regaining control over drug intake (ReCoDe) are still not well described. Our newly formed German Collaborative Research Centre (CRC) on ReCoDe has an interdisciplinary approach funded by the German Research Foundation (DFG) with a 12-year perspective. The main goals of our research consortium are (i) to identify triggers and modifying factors that longitudinally modulate the trajectories of losing and regaining control over drug consumption in real life, (ii) to study underlying behavioral, cognitive, and neurobiological mechanisms, and (iii) to implicate mechanism-based interventions. These goals will be achieved by: (i) using mobile health (m-health) tools to longitudinally monitor the effects of triggers (drug cues, stressors, and priming doses) and modify factors (eg, age, gender, physical activity, and cognitive control) on drug consumption patterns in real-life conditions and in animal models of addiction; (ii) the identification and computational modeling of key mechanisms mediating the effects of such triggers and modifying factors on goal-directed, habitual, and compulsive aspects of behavior from human studies and animal models; and (iii) developing and testing interventions that specifically target the underlying mechanisms for regaining control over drug intake.

引用

页数：6

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