Catalytic role of the C-terminal domains of a fungal non-reducing polyketide synthase

被引：28

作者：

Fisch, Katja M. ^{[1
]}

Skellam, Elizabeth ^{[1
]}

Ivison, David ^{[1
]}

Cox, Russell J. ^{[1
]}

Bailey, Andrew M. ^{[2
]}

Lazarus, Colin M. ^{[2
]}

Simpson, Thomas J. ^{[1
]}

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

[2] Univ Bristol, Sch Biol Sci, Bristol BS8 1UG, Avon, England

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 29期

基金：

英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

NIDULANS-WA GENE; ASPERGILLUS-NIDULANS; PENICILLIUM STIPITATUM; BIOSYNTHESIS; TROPOLONES; MECHANISM; ACIDS;

D O I：

10.1039/c0cc01162b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The in vivo activity of truncated forms of methylorcinaldehyde synthase shows that the synthase retains a hydrolytic release activity in the absence of reductive chain release and that chain-length is not controlled by the reductive release domain; experiments using a methyltransferase inhibitor suggest that methylation occurs prior to aromatisation.

引用

页码：5331 / 5333

页数：3

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