Improving therapeutic resistance: beginning with targeting the tumor microenvironment

被引：3
作者：
Guan, Xiao-ying [1 ]
Guan, Xiao-li [2 ]
Jiao, Zuo-yi [3 ]
机构：
[1] Lanzhou Univ, Hosp 2, Pathol Dept, Lanzhou, Gansu, Peoples R China
[2] Lanzhou Univ, Hosp 2, Gen Med Dept, Lanzhou, Gansu, Peoples R China
[3] Lanzhou Univ, Dept Gen Surg 1, Hosp 2, 82 Cuiying Gate, Lanzhou 730030, Gansu, Peoples R China
来源：
JOURNAL OF CHEMOTHERAPY | 2022年 / 34卷 / 08期
关键词：
Tumor microenvironment; therapeutic resistance; tumor metastasis; target therapy; chemotherapy; immunotherapy; CANCER-ASSOCIATED FIBROBLASTS; CELL LUNG-CANCER; TENASCIN-C; PHASE-I; GLUCOSE-METABOLISM; ANTITUMOR-ACTIVITY; PANCREATIC-CANCER; COLORECTAL-CANCER; OXIDATIVE STRESS; HYPOXIA;
D O I：
10.1080/1120009X.2021.2011661
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cancer is a serious threat to human health and life. The tumor microenvironment (TME) not only plays a key role in the occurrence, development and metastasis of cancer, but also has a profound impact on treatment resistance. To improve and solve this problem, an increasing number of strategies targeting the TME have been proposed, and great progress has been made in recent years. This article reviews the characteristics and functions of the main matrix components of the TME and the mechanisms by which each component affects drug resistance. Furthermore, this article elaborates on targeting the TME as a strategy to treat acquired drug resistance, reduce tumor metastasis, recurrence, and improve efficacy.
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收藏
页码：492 / 516
页数：25
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