Heritability of Human Plasma N-Glycome

被引：28

作者：

Zaytseva, Olga O. ^{[1
]}

Freidin, Maxim B. ^{[2
]}

Keser, Toma ^{[3
]}

Stambuk, Jerko ^{[1
]}

Ugrina, Ivo ^{[1
,4
]}

Simurina, Mirna ^{[3
]}

Vilaj, Marija ^{[1
]}

Stambuk, Tamara ^{[3
]}

Trbojevic-Akmacic, Irena ^{[1
]}

Pucic-Bakovic, Maja ^{[1
]}

Lauc, Gordan ^{[1
,3
]}

Williams, Frances M. K. ^{[2
]}

Novokmet, Mislav ^{[1
]}

机构：

[1] Genos Ltd, Glycosci Res Lab, Borongajska Cesta 83H, Zagreb 10000, Croatia

[2] Kings Coll London, Sch Life Course Sci, Dept Twin Res & Genet Epidemiol, Lambeth Palace Rd, London SE1 7EH, England

[3] Univ Zagreb, Fac Pharm & Biochem, Ante Kovacica 1, Zagreb 10000, Croatia

[4] Univ Split, Fac Sci, Rudera Boskovic 33, Split 21000, Croatia

来源：

JOURNAL OF PROTEOME RESEARCH | 2020年 / 19卷 / 01期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

N-glycosylation; heritability of glycosylation; human plasma glycome; glycan analysis; LOW-BACK-PAIN; IMMUNOGLOBULIN-G; GLYCOSYLATION ANALYSIS; ALPHA-1-ACID GLYCOPROTEIN; ANTIBODY GLYCOSYLATION; FC GLYCANS; IGG; CANCER; ASSOCIATION; MECHANISMS;

D O I：

10.1021/acs.jproteome.9b00348

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The N-glycosylation profile of total human plasma proteins could be a useful biomarker for various pathological states. Reliable high-throughput methods for such profiling have been developed. However, studies of relative importance of genetic and environmental factors in regulating plasma N-glycome are scarce. The aim of our study was to determine the role of genetic factors in phenotypic variation of plasma N-glycan profile through the estimates of its heritability. Thirty-nine total plasma N-glycome traits were analyzed in 2816 individuals from the TwinsUK data set. For the majority of the traits, high heritability estimates (>50%) were obtained pointing at a significant contribution of genetic factors in plasma N-glycome variation, especially for glycans mostly attached to immunoglobulins. We have also found contribution to their variation.

引用

页码：85 / 91

页数：7

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