Heritability of Human Plasma N-Glycome

被引：28

作者：

Zaytseva, Olga O. ^{[1
]}

Freidin, Maxim B. ^{[2
]}

Keser, Toma ^{[3
]}

Stambuk, Jerko ^{[1
]}

Ugrina, Ivo ^{[1
,4
]}

Simurina, Mirna ^{[3
]}

Vilaj, Marija ^{[1
]}

Stambuk, Tamara ^{[3
]}

Trbojevic-Akmacic, Irena ^{[1
]}

Pucic-Bakovic, Maja ^{[1
]}

Lauc, Gordan ^{[1
,3
]}

Williams, Frances M. K. ^{[2
]}

Novokmet, Mislav ^{[1
]}

机构：

[1] Genos Ltd, Glycosci Res Lab, Borongajska Cesta 83H, Zagreb 10000, Croatia

[2] Kings Coll London, Sch Life Course Sci, Dept Twin Res & Genet Epidemiol, Lambeth Palace Rd, London SE1 7EH, England

[3] Univ Zagreb, Fac Pharm & Biochem, Ante Kovacica 1, Zagreb 10000, Croatia

[4] Univ Split, Fac Sci, Rudera Boskovic 33, Split 21000, Croatia

来源：

JOURNAL OF PROTEOME RESEARCH | 2020年 / 19卷 / 01期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

N-glycosylation; heritability of glycosylation; human plasma glycome; glycan analysis; LOW-BACK-PAIN; IMMUNOGLOBULIN-G; GLYCOSYLATION ANALYSIS; ALPHA-1-ACID GLYCOPROTEIN; ANTIBODY GLYCOSYLATION; FC GLYCANS; IGG; CANCER; ASSOCIATION; MECHANISMS;

D O I：

10.1021/acs.jproteome.9b00348

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The N-glycosylation profile of total human plasma proteins could be a useful biomarker for various pathological states. Reliable high-throughput methods for such profiling have been developed. However, studies of relative importance of genetic and environmental factors in regulating plasma N-glycome are scarce. The aim of our study was to determine the role of genetic factors in phenotypic variation of plasma N-glycan profile through the estimates of its heritability. Thirty-nine total plasma N-glycome traits were analyzed in 2816 individuals from the TwinsUK data set. For the majority of the traits, high heritability estimates (>50%) were obtained pointing at a significant contribution of genetic factors in plasma N-glycome variation, especially for glycans mostly attached to immunoglobulins. We have also found contribution to their variation.

引用

页码：85 / 91

页数：7

共 70 条

[1] Building a PGC-LC-MS N-glycan retention library and elution mapping resource [J].

Abrahams, Jodie L. ;

Campbell, Matthew P. ;

Packer, Nicolle H. .

GLYCOCONJUGATE JOURNAL, 2018, 35 (01) :15-29

[2] High-throughput glycomics: Optimization of sample preparation [J].

Akmacic, I. Trbojevic ;

Ugrina, I. ;

Stambuk, J. ;

Gudelj, I. ;

Vuckovic, F. ;

Lauc, G. ;

Pucic-Bakovic, M. .

BIOCHEMISTRY-MOSCOW, 2015, 80 (07) :934-942

[3] Glycosylation as a marker for inflammatory arthritis [J].

Albrecht, Simone ;

Unwin, Louise ;

Muniyappa, Mohankumar ;

Rudd, Pauline M. .

CANCER BIOMARKERS, 2014, 14 (01) :17-28

[4] Evaluation of the serum N-linked glycome for the diagnosis of cancer and chronic inflammation [J].

Arnold, James N. ;

Saldova, Radka ;

Hamid, Umi M. Abd ;

Rudd, Pauline M. .

PROTEOMICS, 2008, 8 (16) :3284-3293

[5] Intact Human Alpha-Acid Glycoprotein Analyzed by ESI-qTOF-MS: Simultaneous Determination of the Glycan Composition of Multiple Glycosylation Sites [J].

Baerenfaenger, Melissa ;

Meyer, Bernd .

JOURNAL OF PROTEOME RESEARCH, 2018, 17 (11) :3693-3703

[6] Immunoglobulin G (IgG) Fab Glycosylation Analysis Using a New Mass Spectrometric High-throughput Profiling Method Reveals Pregnancy-associated Changes [J].

Bondt, Albert ;

Rombouts, Yoann ;

Selman, Maurice H. J. ;

Hensbergen, Paul J. ;

Reiding, Karli R. ;

Hazes, Johanna M. W. ;

Dolhain, Radboud J. E. M. ;

Wuhrer, Manfred .

MOLECULAR & CELLULAR PROTEOMICS, 2014, 13 (11) :3029-3039

[7] IgG and IgM glycosylation patterns in patients undergoing image-guided tumor ablation [J].

Breen, Lucas D. ;

Pucic-Bakovic, Maja ;

Vuckovic, Frano ;

Reiding, Karli ;

Trbojevic-Akmacic, Irena ;

Gajdosik, Martina Srajer ;

Cook, Madeleine I. ;

Lopez, Michael J. ;

Wuhrer, Manfred ;

Camara, L. M. ;

Andjelkovic, Uros ;

Dupuy, Damian E. ;

Josic, Djuro .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2016, 1860 (08) :1786-1794

[8] Noninvasive diagnosis of liver cirrhosis using DNA sequencer-based total serum protein glycomics [J].

Callewaert, N ;

Van Vlierberghe, H ;

Van Hecke, A ;

Laroy, W ;

Delanghe, J ;

Contreras, R .

NATURE MEDICINE, 2004, 10 (04) :429-434

[9] GlycoBase and autoGU: tools for HPLC-based glycan analysis [J].

Campbell, Matthew P. ;

Royle, Louise ;

Radcliffe, Catherine M. ;

Dwek, Raymond A. ;

Rudd, Pauline M. .

BIOINFORMATICS, 2008, 24 (09) :1214-1216

[10] GlycoWorkbench: A tool for the computer-assisted annotation of mass spectra of Glycans [J].

Ceroni, Alessio ;

Maass, Kai ;

Geyer, Hildegard ;

Geyer, Rudolf ;

Dell, Anne ;

Haslam, Stuart M. .

JOURNAL OF PROTEOME RESEARCH, 2008, 7 (04) :1650-1659

← 1 2 3 4 5 6 7 →