Effects of inulin-type fructans, galacto-oligosaccharides and related synbiotics on inflammatory markers in adult patients with overweight or obesity: A systematic review

被引：61
作者：
Fernandes, Ricardo [1 ]
do Rosario, Vinicius A. [1 ]
Mocellin, Michel C. [1 ]
Kuntz, Marilyn G. F. [1 ]
Trindade, Erasmo B. S. M. [1 ,2 ]
机构：
[1] Univ Fed Santa Catarina, Postgrad Program Nutr, Reitor Joao David Ferreira Lima Campus, BR-88040900 Florianopolis, SC, Brazil
[2] Univ Fed Santa Catarina, Dept Nutr, Florianopolis, SC, Brazil
来源：
CLINICAL NUTRITION | 2017年 / 36卷 / 05期
关键词：
Prebiotics; Synbiotics; Overweight; Obesity; Systematic review; CHAIN FATTY-ACIDS; METABOLIC ENDOTOXEMIA; GUT MICROBIOTA; DOUBLE-BLIND; DIABETES-MELLITUS; PREBIOTICS; DIET; RISK; PROBIOTICS; STEATOSIS;
D O I：
10.1016/j.clnu.2016.10.003
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Background & aims: Studies in humans with overweight or obesity have reported that some prebiotics and synbiotics have beneficial effects on metabolic endotoxaemia and immune function. However, to date, no systematic review of controlled clinical trials assessed this topic. The aim of this study was to evaluate the effects of inulin-type fructans, galacto-oligosaccharides and related synbiotics on inflammatory markers in adults with overweight or obesity. Methods: A systematic review of the literature was performed until November 6, 2015 in four electronic databases and reference lists of all included articles and relevant reviews in the field, without using any filter. Results: Ten trials (six prebiotic and four synbiotic trials) representing 534 overweight/obese adults were included. All trials evaluated C-reactive protein or high-sensitivity C-reactive protein, four trials evaluated cytokines (two prebiotic and two synbiotic trials) and five trials evaluated endotoxin (four prebiotic and one synbiotic trials). Six trials (two with galacto-oligosaccharide, one with inulin and three with different synbiotics) showed a reduction on high-sensitivity C-reactive protein. Four trials (one with oligofructose-enriched inulin, one with inulin and two with different synbiotics) showed a reduction on interleukin-6 and/or tumor necrosis factor. Four trials (one with galacto-oligosaccharide, one with oligofrwtose-enriched inulin, one with inulin and one with synbiotic) showed a reduction on endotoxin. Conclusions: Some prebiotics and synbiotics may have immunomodulatory action, however, more randomized controlled trials are needed to support the clinical use of inulin-type fructans, galacto-oligosaccharides or related synbiotics for the treatment of metabolic endotoxaemia or low-grade inflammation in overweight/obese people. (C) 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
引用
收藏
页码：1197 / 1206
页数：10
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