Polymer/Metal Organic Framework (MOF) Nanocomposites for Biomedical Applications

被引：232
作者：
Giliopoulos, Dimitrios [1 ]
Zamboulis, Alexandra [2 ]
Giannakoudakis, Dimitrios [1 ]
Bikiaris, Dimitrios [2 ]
Triantafyllidis, Konstantinos [1 ]
机构：
[1] Aristotle Univ Thessaloniki, Dept Chem, Lab Chem & Environm Technol, GR-54124 Thessaloniki, Greece
[2] Aristotle Univ Thessaloniki, Dept Chem, Lab Polymer Chem & Technol, GR-54124 Thessaloniki, Greece
来源：
MOLECULES | 2020年 / 25卷 / 01期
关键词：
metal organic framework; polymer nanocomposites; drug delivery; magnetic resonance imaging; DRUG-DELIVERY; SURFACE FUNCTIONALIZATION; MATRIX NANOCOMPOSITES; CLICK CHEMISTRY; NANOPARTICLES; COMPOSITES; CONSTRUCTION; ADSORPTION; SIZE; ADSORBENTS;
D O I：
10.3390/molecules25010185
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The utilization of polymer/metal organic framework (MOF) nanocomposites in various biomedical applications has been widely studied due to their unique properties that arise from MOFs or hybrid composite systems. This review focuses on the types of polymer/MOF nanocomposites used in drug delivery and imaging applications. Initially, a comprehensive introduction to the synthesis and structure of MOFs and bio-MOFs is presented. Subsequently, the properties and the performance of polymer/MOF nanocomposites used in these applications are examined, in relation to the approach applied for their synthesis: (i) non-covalent attachment, (ii) covalent attachment, (iii) polymer coordination to metal ions, (iv) MOF encapsulation in polymers, and (v) other strategies. A critical comparison and discussion of the effectiveness of polymer/MOF nanocomposites regarding their synthesis methods and their structural characteristics is presented.
引用
收藏
页数：28
相关论文
共 109 条
[1]   A "green" strategy to construct non-covalent, stable and bioactive coatings on porous MOF nanoparticles [J].
Agostoni, V. ;
Horcajada, P. ;
Noiray, M. ;
Malanga, M. ;
Aykac, A. ;
Jicsinszky, L. ;
Vargas-Berenguel, A. ;
Semiramoth, N. ;
Daoud-Mahammed, S. ;
Nicolas, V. ;
Martineau, C. ;
Taulelle, F. ;
Vigneron, J. ;
Etcheberry, A. ;
Serre, C. ;
Gref, R. .
SCIENTIFIC REPORTS, 2015, 5
[2]   The HSAB concept as a means to interpret the adsorption of metal ions onto activated carbons [J].
Alfarra, A ;
Frackowiak, E ;
Béguin, F .
APPLIED SURFACE SCIENCE, 2004, 228 (1-4) :84-92
[3]  
Alshammari A, 2016, SEMICONDUCTOR PHOTOCATALYSIS - MATERIALS, MECHANISMS AND APPLICATIONS, P301, DOI 10.5772/63489
[4]   Metal-adeninate vertices for the construction of an exceptionally porous metal-organic framework [J].
An, Jihyun ;
Farha, Omar K. ;
Hupp, Joseph T. ;
Pohl, Ehmke ;
Yeh, Joanne I. ;
Rosi, Nathaniel L. .
NATURE COMMUNICATIONS, 2012, 3
[5]   Cation-Triggered Drug Release from a Porous Zinc-Adeninate Metal-Organic Framework [J].
An, Jihyun ;
Geib, Steven J. ;
Rosi, Nathaniel L. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (24) :8376-+
[6]   Biodegradable polymer matrix nanocomposites for tissue engineering: A review [J].
Armentano, I. ;
Dottori, M. ;
Fortunati, E. ;
Mattioli, S. ;
Kenny, J. M. .
POLYMER DEGRADATION AND STABILITY, 2010, 95 (11) :2126-2146
[7]   A non-covalent "click chemistry" strategy to efficiently coat highly porous MOF nanoparticles with a stable polymeric shell [J].
Aykac, Ahmet ;
Noiray, Magali ;
Malanga, Milo ;
Agostoni, Valentina ;
Casas-Solvas, Juan Manuel ;
Fenyvesi, Eva ;
Gref, Ruxandra ;
Vargas-Berenguel, Antonio .
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2017, 1861 (06) :1606-1616
[8]  
Bandosz T.J., 2006, INTERFACE SCI TECHNO, V7, P571
[9]  
Beg S, 2017, DRUG DISCOV TODAY, V22, P625, DOI 10.1016/j.drudis.2016.10.001
[10]   Heparin-Engineered Mesoporous Iron Metal-Organic Framework Nanoparticles: Toward Stealth Drug Nanocarriers [J].
Bellido, Elena ;
Hidalgo, Tania ;
Lozano, Maria Victoria ;
Guillevic, Mazheva ;
Simon-Vazquez, Rosana ;
Santander-Ortega, Manuel J. ;
Gonzalez-Fernandez, Africa ;
Serre, Christian ;
Alonso, Maria J. ;
Horcajada, Patricia .
ADVANCED HEALTHCARE MATERIALS, 2015, 4 (08) :1246-1257
12345678910