Use of the Montreal Cognitive Assessment Thai Version to Discriminate Amnestic Mild Cognitive Impairment from Alzheimer's Disease and Healthy Controls: Machine Learning Results

被引:41
作者
Hemrungrojn, Solaphat [1 ,2 ]
Tangwongchai, Sookjaroen [1 ]
Charoenboon, Thammanard [3 ]
Panasawat, Muthita [4 ]
Supasitthumrong, Thitiporn [1 ]
Chaipresertsud, Pisit [5 ]
Maleevach, Pacharaporn [6 ]
Likitjaroen, Yuttachai [7 ]
Phanthumchinda, Kammant [7 ]
Maes, Michael [1 ,8 ,9 ,10 ]
机构
[1] Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok, Thailand
[2] Chulalongkorn Univ, Cognit Fitness Res Grp, Bangkok, Thailand
[3] Thammasat Univ, Fac Med, Dept Clin Epidemiol, Pathum Thani, Thailand
[4] Thammasat Univ, Fac Med, Dept Psychiat, Pathum Thani, Thailand
[5] Chao Phraya Abhaibhubejhr Hosp, Prachin Buri, Thailand
[6] Angthong Hosp, Ang Thong, Thailand
[7] Chulalongkorn Univ, Fac Med, Dept Med, Div Neurol, Bangkok, Thailand
[8] Med Univ Plovdiv, Dept Psychiat, Plovdiv, Bulgaria
[9] Technol Ctr Emergency Med, Plovdiv, Bulgaria
[10] Deakin Univ, IMPACT Strateg Res Ctr, Geelong, Vic, Australia
关键词
Diagnosis; Montreal Cognitive Assessment; Mild cognitive impairment; Alzheimer's disease; SUBJECTIVE MEMORY COMPLAINTS; BRIEF SCREENING TOOL; ASSESSMENT MOCA; SEMANTIC INTEGRATION; DIAGNOSTIC-ACCURACY; TEST-PERFORMANCE; DEMENTIA; VALIDATION; VALIDITY; INSTRUMENTS;
D O I
10.1159/000517822
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background: The Montreal Cognitive Assessment (MoCA) is an effective and applicable screening instrument to confirm the diagnosis of amnestic mild cognitive impairment (aMCI) from patients with Alzheimer's disease (AD) and healthy controls (HCs). Objectives: This study aimed to determine the reliability and validity of the following: (a) Thai translation of the MoCA (MoCA-Thai) and (b) delineate the key features of aMCI based on the MoCA subdomains. Methods: This study included 60 HCs, 61 aMCI patients, and 60 AD patients. The MoCA-Thai shows adequate psychometric properties including internal consistency, concurrent validity, test-retest validity, and inter-rater reliability. Results: The MoCA-Thai may be employed as a diagnostic criterion to make the diagnosis of aMCI, whereby aMCI patients are discriminated from HC with an area under the receiver-operating characteristic (AUC-ROC) curve of 0.813 and from AD patients with an AUC-ROC curve of 0.938. The best cutoff scores of the MoCA-Thai to discriminate aMCI from HC is <= 24 and from AD > 16. Neural network analysis showed that (a) aberrations in recall was the most important feature of aMCI versus HC with impairments in language and orientation being the second and third most important features and (b) aberrations in visuospatial skills and executive functions were the most important features of AD versus aMCI and that impairments in recall, language, and orientation but not attention, concentration, and working memory, further discriminated AD from aMCI. Conclusions: The MoCA-Thai is an appropriate cognitive assessment tool to be used in the Thai population for the diagnosis of aMCI and AD.
引用
收藏
页码:183 / 194
页数:12
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