Colloidal micelles of block copolymers as nanoreactors, templates for gold nanoparticles, and vehicles for biomedical applications

被引:49
作者
Bakshi, Mandeep Singh [1 ]
机构
[1] Wilfrid Laurier Univ, Dept Chem, Waterloo, ON N2L 3C5, Canada
关键词
Block copolymer micelles; Gold nanoparticles; Nanoreactors; Biomedical applications; TRIBLOCK COPOLYMER; POLYMERIC MICELLES; IONIC SURFACTANTS; MIXED MICELLES; INORGANIC NANOPARTICLES; MULTIPLE MORPHOLOGIES; CATALYTIC-PROPERTIES; RADIATION-THERAPY; METHYL-ORANGE; PLURONIC F127;
D O I
10.1016/j.cis.2014.08.001
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Target drug delivery methodology is becoming increasingly important to overcome the shortcomings of conventional drug delivery absorption method. It improves the action time with uniform distribution and poses minimum side effects, but is usually difficult to design to achieve the desire results. Economically favorable, environment friendly, multifunctional, and easy to design, hybrid nanomaterials have demonstrated their enormous potential as target drug delivery vehicles. A combination of both micelles and nanoparticles makes them fine target delivery vehicles in a variety of biological applications where precision is primarily required to achieve the desired results as in the case of cytotoxicity of cancer cells, chemotherapy, and computed tomography guided radiation therapy. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码:1 / 20
页数:20
相关论文
共 138 条
[1]   Remote Triggered Release of Doxorubicin in Tumors by Synergistic Application of Thermosensitive Liposomes and Gold Nanorods [J].
Agarwal, Abhiruchi ;
Mackey, Megan A. ;
El-Sayed, Mostafa A. ;
Bellamkonda, Ravi V. .
ACS NANO, 2011, 5 (06) :4919-4926
[2]   Nanoscale patterning of two metals on silicon surfaces using an ABC triblock copolymer template [J].
Aizawa, M ;
Buriak, JM .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (17) :5877-5886
[3]   Gold-Loaded Polymeric Micelles for Computed Tomography-Guided Radiation Therapy Treatment and Radiosensitization [J].
Al Zaki, Ajlan ;
Joh, Daniel ;
Cheng, Zhiliang ;
De Barros, Andre Luis Branco ;
Kao, Gary ;
Dorsey, Jay ;
Tsourkas, Andrew .
ACS NANO, 2014, 8 (01) :104-112
[4]   PLURONIC-P105 PEO-PPO-PEO BLOCK-COPOLYMER IN AQUEOUS UREA SOLUTIONS - MICELLE FORMATION, STRUCTURE, AND MICROENVIRONMENT [J].
ALEXANDRIDIS, P ;
ATHANASSIOU, V ;
HATTON, TA .
LANGMUIR, 1995, 11 (07) :2442-2450
[5]   TEMPERATURE EFFECTS ON STRUCTURAL-PROPERTIES OF PLURONIC P104 AND F108 PEO-PPO-PEO BLOCK-COPOLYMER SOLUTIONS [J].
ALEXANDRIDIS, P ;
NIVAGGIOLI, T ;
HATTON, TA .
LANGMUIR, 1995, 11 (05) :1468-1476
[6]   The use of nanocrystals in biological detection [J].
Alivisatos, P .
NATURE BIOTECHNOLOGY, 2004, 22 (01) :47-52
[7]   Thermosensitive pluronic micelles stabilized by shell cross-linking with gold nanoparticles [J].
Bae, Ki Hyun ;
Choi, Seung Ho ;
Park, Sung Young ;
Lee, Yuhan ;
Park, Tae Gwan .
LANGMUIR, 2006, 22 (14) :6380-6384
[8]   Dependence of crystal growth of gold nanoparticles on the capping behavior of surfactant at ambient conditions [J].
Bakshi, Mandeep Singh ;
Sachar, Shweta ;
Kaur, Gurpreet ;
Bhandari, Poonam ;
Kaur, Gurinder ;
Biesinger, Mark C. ;
Possmayer, Fred ;
Petersen, Nils O. .
CRYSTAL GROWTH & DESIGN, 2008, 8 (05) :1713-1719
[9]   Role of different phospholipids in the synthesis of pearl-necklace-type gold-silver bimetallic nanoparticles as bioconjugate materials [J].
Bakshi, Mandeep Singh ;
Possmayer, Fred ;
Petersen, Nils O. .
JOURNAL OF PHYSICAL CHEMISTRY C, 2007, 111 (38) :14113-14124
[10]   Surfactant selective synthesis of gold nanowires by using a DPPC-surfactant mixture as a capping agent at ambient conditions [J].
Bakshi, Mandeep Singh ;
Kaur, Gurpreet ;
Thakur, Pankaj ;
Banipal, Tarlok Singh ;
Possmayer, Fred ;
Petersen, Nils O. .
JOURNAL OF PHYSICAL CHEMISTRY C, 2007, 111 (16) :5932-5940