Comparison of Circuits for Generating Nonthermal Plasma to Treat Melanoma Cells

被引：1

作者：

Thompson, Kyle ^{[1
]}

Zirnheld, Jennifer ^{[1
]}

Burke, Kevin ^{[1
]}

Zucker, Shoshanna N. ^{[2
]}

机构：

[1] Univ Buffalo, Dept Elect Engn, Energy Syst Integrat, 230 Davis Hall, Buffalo, NY 14260 USA

[2] DYouville Coll, Sch Pharm, 320 Porter Ave, Buffalo, NY 14201 USA

来源：

IEEE TRANSACTIONS ON DIELECTRICS AND ELECTRICAL INSULATION | 2017年 / 24卷 / 04期

关键词：

plasma applications; biological cells; resonance; transformers; cancer; helium; plasma torches; BARRIER DISCHARGE PLASMA; BIOMEDICAL APPLICATIONS; NEEDLE;

D O I：

10.1109/TDEI.2017.006288

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Nonthermal plasma has shown promising results as a treatment method for melanoma cancer cells. To generate the high voltage AC signal required to ionize helium, a resonance transformer is used. This work compares two circuits, a manual tuning circuit and an automatic tuning circuit, that have been developed to generate the frequency required to achieve resonance. The design and performance of each circuit are presented, and the electrical and plasma characteristics are compared. The utilization of both circuits in the treatment of two melanoma cell lines show statistically indistinguishable results in cell viability assays, as well as similar cell death morphological characteristics.

引用

页码：2241 / 2247

页数：7

共 30 条

[21] Nonthermal plasma applications to the environment: Gaseous electronics and power conditioning
Rosocha, LA
[J]. IEEE TRANSACTIONS ON PLASMA SCIENCE, 2005, 33 (01) : 129 - 137
[22] Neutral gas flow and ring-shaped emission profile in non-thermal RF-excited plasma needle discharge at atmospheric pressure
Sakiyama, Yukinori
Graves, David B.
[J]. PLASMA SOURCES SCIENCE & TECHNOLOGY, 2009, 18 (02)
[23] Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases
Smalley, KSM
Haass, NK
Brafford, PA
Lioni, M
Flaherty, KT
Herlyn, M
[J]. MOLECULAR CANCER THERAPEUTICS, 2006, 5 (05) : 1136 - 1144
[24] Plasma needle for in vivo medical treatment:: recent developments and perspectives
Stoffels, E.
Kieft, I. E.
Sladek, R. E. J.
van den Bedem, L. J. M.
van der Laan, E. P.
Steinbuch, M.
[J]. PLASMA SOURCES SCIENCE & TECHNOLOGY, 2006, 15 (04) : S169 - S180
[25] Plasma needle: a non-destructive atmospheric plasma source for fine surface treatment of (bio)materials
Stoffels, E
Flikweert, AJ
Stoffels, WW
Kroesen, GMW
[J]. PLASMA SOURCES SCIENCE & TECHNOLOGY, 2002, 11 (04) : 383 - 388
[26] Cold Plasma: A novel Non-Thermal Technology for Food Processing
Thirumdas, Rohit
Sarangapani, Chaitanya
Annapure, Uday S.
[J]. FOOD BIOPHYSICS, 2015, 10 (01) : 1 - 11
[27] Free radicals, metals and antioxidants in oxidative stress-induced cancer
Valko, M
Rhodes, CJ
Moncol, J
Izakovic, M
Mazur, M
[J]. CHEMICO-BIOLOGICAL INTERACTIONS, 2006, 160 (01) : 1 - 40
[28] Nonthermal Plasma Needle: Development and Targeting of Melanoma Cells
Zirnheld, Jennifer L.
Zucker, Shoshanna N.
DiSanto, Thomas M.
Berezney, Ronald
Etemadi, Kasra
[J]. IEEE TRANSACTIONS ON PLASMA SCIENCE, 2010, 38 (04) : 948 - 952
[29] A dominant negative Cx43 mutant differentially affects tumorigenic and invasive properties in human metastatic melanoma cells
Zucker, Shoshanna N.
Bancroft, Tara A.
Place, David E.
Des Soye, Benjamin
Bagati, Archis
Berezney, Ronald
[J]. JOURNAL OF CELLULAR PHYSIOLOGY, 2013, 228 (04) : 853 - 859
[30] Preferential induction of apoptotic cell death in melanoma cells as compared with normal keratinocytes using a non-thermal plasma torch
Zucker, Shoshanna N.
Zirnheld, Jennifer
Bagati, Archis
DiSanto, Thomas M.
Des Soye, Benjamin
Wawrzyniak, Joseph A.
Etemadi, Kasra
Nikiforov, Mikhail
Berezney, Ronald
[J]. CANCER BIOLOGY & THERAPY, 2012, 13 (13) : 1299 - 1306

← 1 2 3 →