The Immunopathophysiology of Multiple Sclerosis

被引：111

作者：

Wu, Gregory F. ^{[1
]}

Alvarez, Enrique ^{[1
]}

机构：

[1] Washington Univ, Div Multiple Sclerosis, Dept Neurol, St Louis, MO 63110 USA

来源：

NEUROLOGIC CLINICS | 2011年 / 29卷 / 02期

关键词：

Multiple sclerosis; Neuroimmunology; Demyelination; Pathogenesis; MYELIN BASIC-PROTEIN; CENTRAL-NERVOUS-SYSTEM; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; APPEARING WHITE-MATTER; BLOOD-BRAIN-BARRIER; T-CELL RESPONSES; ANTIGEN-PRESENTING CELLS; EXPANDED PLASMA-CELLS; HELPER; 17; CELLS; CEREBROSPINAL-FLUID;

D O I：

10.1016/j.ncl.2010.12.009

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This review explores the principle features of the immunopathology of multiple sclerosis (MS), particularly relapsing-remitting MS. It highlights the emerging concepts in the pathogenesis of MS in the context of known features of pathology, including the characterization of cytokine networks promoting inflammatory damage of the central nervous system, B-cell involvement, and inflammatory damage of axons and neurons. This article preferentially focuses on MS rather than animal models of the disease, such as experimental autoimmune encephalomyelitis.

引用

页码：257 / +

页数：24

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