Influence of Maternal Nutritional Status on Vascular Function in the Offspring

被引:19
作者
Poston, Lucilla [1 ,2 ,3 ]
机构
[1] Kings Coll London, Div Womens Hlth, Sch Med, London WC2R 2LS, England
[2] Kings Hlth Partners, London, England
[3] Kings Coll London, Maternal & Fetal Res Unit, Sch Med, London WC2R 2LS, England
关键词
developmental programming; maternal; nutrition; offspring; cardiovascular; DIET-INDUCED OBESITY; CORONARY-HEART-DISEASE; LOW-BIRTH-WEIGHT; SYMPATHETIC-NERVE ACTIVITY; ELEVATED BLOOD-PRESSURE; GROWTH IN-UTERO; BODY-MASS INDEX; HIGH-FAT DIET; ADULT HYPERTENSION; INSULIN-RESISTANCE;
D O I
10.1111/j.1549-8719.2011.00086.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
P>Suboptimal maternal nutritional status has been implicated in the development of cardiovascular risk in the child. Initially inferred from studies of low-birthweight children, investigations in cohorts of women subjected to famine provide direct evidence for an independent influence of the mother's diet on the cardiovascular health of her child. Animal studies from rodents and sheep have shown associations between maternal undernutrition and raised blood pressure, as well as abnormalities in resistance artery function, particularly in endothelium-dependent responses. Early life exposure to the influences of maternal over nutritional states, e.g. obesity and excessive gestational weight gain, has also been associated with markers of cardiovascular risk in man, and animal models have shown raised blood pressure and endothelial dysfunction in offspring of diet-induced obese dams. Increased sympathetic tone is commonly associated with hypertension in animal models of both under nutritional and over nutritional states. This and several other similarities may indicate commonality of mechanism and could reflect supranormal nutritional status in postnatal life in both conditions.
引用
收藏
页码:256 / 262
页数:7
相关论文
共 69 条
[61]   Promotion of faster weight gain in infants born small for gestational age - Is there an adverse effect on later blood pressure? [J].
Singhal, Atul ;
Cole, Tim J. ;
Fewtrell, Mary ;
Kennedy, Kathy ;
Stephenson, Terence ;
Elias-Jones, Alun ;
Lucas, Alan .
CIRCULATION, 2007, 115 (02) :213-220
[62]   Aortic wall thickness in newborns with intrauterine growth restriction [J].
Skilton, MR ;
Evans, N ;
Griffiths, KA ;
Harmer, JA ;
Celermajer, DS .
LANCET, 2005, 365 (9469) :1484-1486
[63]   Maternal high-fat diet consumption results in fetal malprogramming predisposing to the onset of metabolic syndrome-like phenotype in adulthood [J].
Srinivasan, Malathi ;
Katewa, Subhash D. ;
Palaniyappan, Arivazhagan ;
Pandya, Jignesh D. ;
Patel, Mulchand S. .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2006, 291 (04) :E792-E799
[64]   Does malnutrition in utero determine diabetes and coronary heart disease in adulthood? Results from the Leningrad siege study, a cross sectional study [J].
Stanner, SA ;
Bulmer, K ;
Andres, C ;
Lantseva, OE ;
Borodina, V ;
Poteen, VV ;
Yudkin, JS .
BMJ-BRITISH MEDICAL JOURNAL, 1997, 315 (7119) :1342-1348
[65]   Melanocortin-4 receptor mediates chronic cardiovascular and metabolic leptin [J].
Tallam, Lakshmi S. ;
da Silva, Alexandre A. ;
Hall, John E. .
HYPERTENSION, 2006, 48 (01) :58-64
[66]   Maternal and child undernutrition 2 - Maternal and child undernutrition: consequences for adult health and human capital [J].
Victora, Cesar G. ;
Adair, Linda ;
Fall, Caroline ;
Hallal, Pedro C. ;
Martorell, Reynaldo ;
Richter, Linda ;
Sachdev, Harshpal Singh .
LANCET, 2008, 371 (9609) :340-357
[67]   Perinatal Maternal Fat Intake Affects Metabolism and Hippocampal Function in the Offspring A Potential Role for Leptin [J].
Walker, Claire-Dominique ;
Naef, Lindsay ;
d'Asti, Esterina ;
Long, Hong ;
Xu, Zhifang ;
Moreau, Alain ;
Azeddine, Bouziane .
NEURAL SIGNALING: OPPORTUNITIES FOR NOVEL DIAGNOSTIC APPROACHES AND THERAPIES, 2008, 1144 :189-202
[68]   Cardiovascular risk factors in children exposed to maternal diabetes in utero [J].
West, N. A. ;
Crume, T. L. ;
Maligie, M. A. ;
Dabelea, D. .
DIABETOLOGIA, 2011, 54 (03) :504-507
[69]   Chronic maternal undernutrition in the rat leads to delayed postnatal growth and elevated blood pressure of offspring [J].
Woodall, SM ;
Johnston, BM ;
Breier, BH ;
Gluckman, PD .
PEDIATRIC RESEARCH, 1996, 40 (03) :438-443