A facile tandem reaction to access β-hydroxy-α,α-difluoroketone derivatives catalyzed by titanocene dichloride/magnesium

被引：5
作者：
Wu, Lei [1 ]
机构：
[1] Harbin Inst Technol, Acad Fundamental & Interdisciplinary Sci, Harbin 150080, Peoples R China
来源：
JOURNAL OF FLUORINE CHEMISTRY | 2011年 / 132卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Tandem reaction; Barbier-type allylation; Brook rearrangement; Fluoride-promoted aldol reaction; ENOL SILYL ETHERS; ALDOL REACTIONS; ACYLSILANES; KETONES; TRIFLUOROMETHYLTRIMETHYLSILANE; HYDROGENATION; ALLYLATION; CHEMISTRY; SILANES; ACIDS;
D O I：
10.1016/j.jfluchem.2011.03.014
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Tandem reactions of Barbier-type allylation, Brook rearrangement and fluoride-promoted aldol reaction were developed, which afforded a facile, "one-pot" process to beta-hydroxy-alpha,alpha-difluoroketone derivatives with good to excellent yields. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：367 / 372
页数：6
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