Hydroxy double salts as versatile storage and delivery matrices

被引：37

作者：

Bull, Richard M. R. ^{[1
]}

Markland, Charles ^{[1
]}

Williams, Gareth R. ^{[1
]}

O'Hare, Dermot ^{[1
]}

机构：

[1] Univ Oxford, Chem Res Lab, Oxford OX1 3TA, England

来源：

JOURNAL OF MATERIALS CHEMISTRY | 2011年 / 21卷 / 06期

关键词：

LAYERED DOUBLE HYDROXIDES; ANION-EXCHANGE REACTIONS; CONTROLLED-RELEASE PROPERTIES; INTERCALATION; KINETICS; SYSTEM; COPPER; CLINOPTILOLITE; DECOMPOSITION; NANOHYBRIDS;

D O I：

10.1039/c0jm03020a

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The utility of hydroxy double salts (HDSs) for the uptake and delivery of a range of functional anions via ion exchange is demonstrated. Three novel HDS nanocomposites containing medicinal (ibuprofen and diclofenac) and agrochemical (2,4,5-trichlorophenoxyacetic acid) species have been synthesised through ion exchange intercalation. The release of the guest ions from the host has subsequently been explored. A range of models have been applied to the release kinetics. Release of 2,4,5-trichlorophenoxyacetic acid took place over ca. 200 minutes and release of ibuprofen over around 250 minutes. Coating the crystallites of the intercalates with a sodium alginate layer led to release times being extended to approximately 10 hours, which is an appropriate timescale for an effective release system.

引用

页码：1822 / 1828

页数：7

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