Is insulin an antiinflammatory molecule?

被引:136
作者
Das, UN [1 ]
机构
[1] EFA Sci LLC, Norwood, MA 02062 USA
关键词
insulin; tumor necrosis factor; inflammation; macrophage migration inhibitory factor; diabetes mellitus;
D O I
10.1016/S0899-9007(01)00518-4
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
I suggest that insulin suppresses the secretion and antagonizes the harmful effects of tumor necrosis factor-alpha, macrophage migration-inhibitory factor, and superoxide anion. Therefore, the glucose-insulin-potassium regimen might be beneficial in acute myocardial infarction and useful in the management of patients with septicemia, septic shock, and other inflammatory diseases in which tumor necrosis factor-a and macrophage migration-inhibitory factor have important roles.
引用
收藏
页码:409 / 413
页数:5
相关论文
共 82 条
[41]   Insulin-like growth factors-I and -II differentially regulate endogenous acetylcholine release from the rat hippocampal formation [J].
Kar, S ;
Seto, D ;
Dore, S ;
Hanisch, UK ;
Quirion, R .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (25) :14054-14059
[42]   Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo A specific vascular action of insulin [J].
Kuboki, K ;
Jiang, ZY ;
Takahara, N ;
Ha, SW ;
Igarashi, M ;
Yamauchi, T ;
Feener, EP ;
Herbert, TP ;
Rhodes, CJ ;
King, GL .
CIRCULATION, 2000, 101 (06) :676-681
[43]  
KUMAR GS, 1994, PROSTAG LEUKOTR ESS, V50, P331
[44]  
LANG CH, 1989, CIRC SHOCK, V28, P165
[45]   SEPSIS-INDUCED CHANGES IN INVIVO INSULIN ACTION IN DIABETIC RATS [J].
LANG, CH ;
DOBRESCU, C .
AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 257 (03) :E301-E308
[46]   Polyunsaturated fatty acids are potent neuroprotectors [J].
Lauritzen, I ;
Blondeau, N ;
Heurteaux, C ;
Widmann, C ;
Romey, G ;
Lazdunski, M .
EMBO JOURNAL, 2000, 19 (08) :1784-1793
[47]   LIMITING ISCHEMIC MYOCARDIAL DAMAGE USING GLUCOSE-INSULIN-POTASSIUM SOLUTIONS [J].
LAZAR, HL ;
ZHANG, X ;
RIVERS, S ;
BERNARD, S ;
SHEMIN, RJ .
ANNALS OF THORACIC SURGERY, 1995, 60 (02) :411-416
[48]   ELEVATED CIRCULATING LEVELS OF TUMOR-NECROSIS-FACTOR IN SEVERE CHRONIC HEART-FAILURE [J].
LEVINE, B ;
KALMAN, J ;
MAYER, L ;
FILLIT, HM ;
PACKER, M .
NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (04) :236-241
[49]   Kinetics of tumor necrosis factor α in plasma and the cardioprotective effect of a monoclonal antibody to tumor necrosis factor α in acute myocardial infarction [J].
Li, DY ;
Zhao, L ;
Liu, ML ;
Du, XP ;
Ding, WH ;
Zhang, JH ;
Mehta, JL .
AMERICAN HEART JOURNAL, 1999, 137 (06) :1145-1152
[50]  
Lind L, 1994, Clin Intensive Care, V5, P100