Is insulin an antiinflammatory molecule?

被引:136
作者
Das, UN [1 ]
机构
[1] EFA Sci LLC, Norwood, MA 02062 USA
关键词
insulin; tumor necrosis factor; inflammation; macrophage migration inhibitory factor; diabetes mellitus;
D O I
10.1016/S0899-9007(01)00518-4
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
I suggest that insulin suppresses the secretion and antagonizes the harmful effects of tumor necrosis factor-alpha, macrophage migration-inhibitory factor, and superoxide anion. Therefore, the glucose-insulin-potassium regimen might be beneficial in acute myocardial infarction and useful in the management of patients with septicemia, septic shock, and other inflammatory diseases in which tumor necrosis factor-a and macrophage migration-inhibitory factor have important roles.
引用
收藏
页码:409 / 413
页数:5
相关论文
共 82 条
[1]   Why immunomodulatory therapies have not worked in sepsis [J].
Abraham, E .
INTENSIVE CARE MEDICINE, 1999, 25 (06) :556-566
[2]   Insulin inhibits the expression of intercellular adhesion molecule-1 by human aortic endothelial cells through stimulation of nitric oxide [J].
Aljada, A ;
Saadeh, R ;
Assian, E ;
Ghanim, H ;
Dandona, P .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (07) :2572-2575
[3]  
BAKER AL, 1981, GASTROENTEROLOGY, V80, P1410
[4]   Endotoxin-induced acute lung injury in rats. Role of insulin [J].
Boichot, E ;
Sannomiya, P ;
Escofier, N ;
Germain, N ;
Fortes, ZB ;
Lagente, V .
PULMONARY PHARMACOLOGY & THERAPEUTICS, 1999, 12 (05) :285-290
[5]   Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin [J].
Borovikova, LV ;
Ivanova, S ;
Zhang, MH ;
Yang, H ;
Botchkina, GI ;
Watkins, LR ;
Wang, HC ;
Abumrad, N ;
Eaton, JW ;
Tracey, KJ .
NATURE, 2000, 405 (6785) :458-462
[6]   Anti-inflammatory drugs protect against Alzheimer disease at low doses [J].
Broe, GA ;
Grayson, DA ;
Creasey, HM ;
Waite, LM ;
Casey, BJ ;
Bennett, HP ;
Brooks, WS ;
Halliday, GM .
ARCHIVES OF NEUROLOGY, 2000, 57 (11) :1586-1591
[7]   MYOCARDIAL METABOLIC AND MORPHOMETRIC CHANGES DURING CANINE ENDOTOXIN-SHOCK BEFORE AND AFTER GLUCOSE-INSULIN-POTASSIUM [J].
BRONSVELD, W ;
VANLAMBALGEN, AA ;
VANVELZEN, D ;
VANDENBOS, GC ;
KOOPMAN, PAR ;
THIJS, LG .
CARDIOVASCULAR RESEARCH, 1985, 19 (08) :455-464
[8]   SEPSIS-INDUCED CASCADE OF CYTOKINE MESSENGER-RNA EXPRESSION - CORRELATION WITH METABOLIC CHANGES [J].
BYERLEY, LO ;
ALCOCK, NW ;
STARNES, HF .
AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 262 (05) :E728-E735
[9]   Therapeutic strategies to reduce TNF-α mediated cardiac contractile depression following ischemia and reperfusion [J].
Cain, BS ;
Harken, AH ;
Meldrum, DR .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1999, 31 (05) :931-947
[10]   Protection from septic shock by neutralization of macrophage migration inhibitory factor [J].
Calandra, T ;
Echtenacher, B ;
Le Roy, D ;
Pugin, J ;
Metz, CN ;
Hültner, L ;
Heumann, D ;
Männel, D ;
Bucala, R ;
Glauser, MP .
NATURE MEDICINE, 2000, 6 (02) :164-170