In vitro activity of the antimicrobial peptides h-Lf1-11, MSI-78, LL-37, fengycin 2B, and magainin-2 against clinically important bacteria

被引：17

作者：

Denardi, Laura Bedin ^{[1
,2
]}

Trindade, Priscila de Arruda ^{[3
,4
]}

Weiblen, Carla ^{[5
]}

Ianiski, Lara Baccarin ^{[1
,4
]}

Stibbe, Paula Cristina ^{[1
,4
]}

Pinto, Stefania Campos ^{[1
]}

Santurio, Janio Morais ^{[1
]}

机构：

[1] Fed Univ Santa Maria UFSM, Dept Microbiol & Parasitol, Ave Roraima,N o1000,Predio 20,Sala 4139, BR-97105900 Santa Maria, RS, Brazil

[2] Fed Univ Santa Maria UFSM, Pharmacol Postgrad Program, Santa Maria, RS, Brazil

[3] Fed Univ Santa Maria UFSM, Hlth Sci Ctr, Santa Maria, RS, Brazil

[4] Fed Univ Santa Maria UFSM, Pharmaceut Sci Postgrad Program, Santa Maria, RS, Brazil

[5] Reg Integrated Univ Alto Uruguay & Missions URI S, Santiago, RS, Brazil

来源：

BRAZILIAN JOURNAL OF MICROBIOLOGY | 2022年 / 53卷 / 01期

关键词：

Antimicrobial peptides; Pexiganan; Antibiotic resistance; MSI-78; Antibacterial activity; N-TERMINAL PEPTIDE; HUMAN LACTOFERRIN; ANTIBACTERIAL; CATHELICIDINS; MEMBRANE;

D O I：

10.1007/s42770-021-00645-6

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We investigated the antibacterial activity of the antimicrobial peptides h-Lf1-11, MSI-78, LL-37, fengycin 2B, and magainin-2. The minimum inhibitory concentration (MIC) was determined by microdilution technique according to CLSI (M07-A9, 2012) against Escherichia coli, methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa, carbapenem-resistant Klebsiella pneumoniae, and Acinetobacter baumannii. The MSI-78 showed potent bactericidal activity with MIC range of 1.25-40 mg/L against all bacterial strains. The h-Lf1-11, magainin-2, and LL-37 exhibited moderate activity (MIC range of 40-160, 80-160, and 40-160 mg/L, respectively) while the fengycin 2B did not show significant activity against all bacterial strains tested. These results revealed that MSI-78, h-Lf1-11, magainin-2, and LL-37 have great potential as antibacterial agents and their activity deserves to be more explored in further studies for the treatment of antibiotic-resistant bacteria.

引用

页码：171 / 177

页数：7

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