Genetic and epigenetic basis of psoriasis pathogenesis

被引：135
作者：
Chandra, Aditi [1 ]
Ray, Aditi [1 ]
Senapati, Swapan [2 ]
Chatterjee, Raghunath [1 ]
机构：
[1] Indian Stat Inst, Human Genet Unit, Kolkata 700108, India
[2] Uttarpara, Hooghly 712258, India
来源：
MOLECULAR IMMUNOLOGY | 2015年 / 64卷 / 02期
关键词：
Generalized plaque type psoriasis; DNA methylation; Micro RNA; Histone modifications; Single nucleotide polymorphism; Genome-wide association study; GENOME-WIDE ASSOCIATION; EPIDERMAL DIFFERENTIATION COMPLEX; PROMOTER METHYLATION STATUS; LEUKOCYTE ANTIGEN HLA; RUNX1; BINDING-SITE; FOLLOW-UP ANALYSIS; SUSCEPTIBILITY LOCUS; FAMILIAL PSORIASIS; CHINESE POPULATION; ATOPIC-DERMATITIS;
D O I：
10.1016/j.molimm.2014.12.014
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Psoriasis is a chronic inflammatory skin disease whose prevalence varies among different populations worldwide. It is a complex multi-factorial disease and the exact etiology is largely unknown. Family based studies have indicated a genetic predisposition; however they cannot fully explain the disease pathogenesis. In addition to genetic susceptibility, environmental as well as gender and age related factors were also been found to be associated. Recently, imbalances in epigenetic networks are indicated to be causative elements in psoriasis. The present knowledge of epigenetic involvement, mainly the DNA methylation, chromatin modifications and miRNA deregulation is surveyed here. An integrated approach considering genetic and epigenetic anomalies in the light of immunological network may explore the pathogenesis of psoriasis. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：313 / 323
页数：11
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