Myocardial Lineage Development

被引：206
作者：
Evans, Sylvia M. [1 ]
Yelon, Deborah [2 ]
Conlon, Frank L. [3 ]
Kirby, Margaret L. [4 ,5 ]
机构：
[1] Univ Calif San Diego, Dept Med, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Div Biol Sci, La Jolla, CA 92093 USA
[3] Univ N Carolina, Dept Genet, Chapel Hill, NC USA
[4] Duke Univ, Dept Pediat, Durham, NC 27710 USA
[5] Duke Univ, Dept Cell Biol, Durham, NC 27710 USA
来源：
CIRCULATION RESEARCH | 2010年 / 107卷 / 12期
关键词：
myocardial lineages; specification; differentiation; transcriptional regulation; signaling; heart development; CARDIAC CONDUCTION SYSTEM; 2ND HEART FIELD; BONE MORPHOGENETIC PROTEIN; LEFT-RIGHT ASYMMETRY; ENDOTHELIN-CONVERTING ENZYME-1; BHLH TRANSCRIPTION FACTOR; HOLT-ORAM-SYNDROME; T-BOX FACTORS; EMBRYONIC HEART; OUTFLOW TRACT;
D O I：
10.1161/CIRCRESAHA.110.227405
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The myocardium of the heart is composed of multiple highly specialized myocardial lineages, including those of the ventricular and atrial myocardium, and the specialized conduction system. Specification and maturation of each of these lineages during heart development is a highly ordered, ongoing process involving multiple signaling pathways and their intersection with transcriptional regulatory networks. Here, we attempt to summarize and compare much of what we know about specification and maturation of myocardial lineages from studies in several different vertebrate model systems. To date, most research has focused on early specification, and although there is still more to learn about early specification, less is known about factors that promote subsequent maturation of myocardial lineages required to build the functioning adult heart. (Circ Res. 2010; 107: 1428-1444.)
引用
收藏
页码：1428 / 1444
页数：17
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