Effect of laparoscopic ovarian drilling on vascular endothelial growth factor and ovarian stromal blood flow using 3-dimensional power Doppler

被引：29

作者：

El Behery, Manal M. ^{[1
]}

Diab, Abdalla E. ^{[1
]}

Mowafy, Hala ^{[1
]}

Ebrahiem, Moustafa A. ^{[1
]}

Shehata, Amal E. ^{[2
]}

机构：

[1] Zagazig Univ, Fac Med, Dept Obstet & Gynecol, Zagazig, Egypt

[2] Zagazig Univ, Fac Med, Dept Biochem, Zagazig, Egypt

来源：

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS | 2011年 / 112卷 / 02期

关键词：

3D power Doppler; Laparoscopic ovarian drilling; Polycystic ovary syndrome; Vascular endothelial growth factor; POLYCYSTIC-OVARY; WOMEN; ULTRASONOGRAPHY; DEFINITIONS; SONOGRAPHY; DIAGNOSIS; CONSENSUS; MARKER;

D O I：

10.1016/j.ijgo.2010.08.018

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To determine, by using 3-dimensional power Doppler ultrasonography, the effect of laparoscopic ovarian drilling (LOD) on the serum level of vascular endothelial growth factor (VEGF) and ovarian stromal blood flow changes in polycystic ovary syndrome (PCOS). Methods: A prospective controlled clinical study was conducted on 26 clomiphene-resistant women with PCOS who were scheduled for LOD and a control group of 22 fertile regularly menstruating women. VEGF and 3 ovarian Doppler indices vascularization index, flow index, and vascularization flow index were measured and compared between the 2 groups, and before and after LOD in the PCOS group. Results: Serum VEGF and the Doppler indices of ovarian stromal blood flow were significantly higher in the PCOS group than in the control group. Serum VEGF and the ovarian stromal blood flow Doppler indices were significantly reduced in the PCOS group after LOD. Conclusion: Increased vascularity in PCOS demonstrated by Doppler blood flow measurements might be explained by the high level of VEGF. LOD reduced ovarian vascularization and serum VEGF. (C) 2010 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

引用

页码：119 / 121

页数：3

共 18 条

[11]

KAMAT BR, 1995, AM J PATHOL, V146, P157

[12] Comparison of ovarian stromal blood flow between fertile women with normal ovaries and infertile women with polycystic ovary syndrome [J].

Ng, EHY ;

Chan, CCW ;

Yeung, WSB ;

Ho, PC .

HUMAN REPRODUCTION, 2005, 20 (07) :1881-1886

[13] Three-dimensional power Doppler sonography: imaging and quantifying blood flow and vascularization [J].

Pairleitner, H ;

Steiner, H ;

Hasenoehrl, G ;

Staudach, A .

ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 1999, 14 (02) :139-143

[14] Quantification of Doppler signal in polycystic ovary syndrome using three-dimensional power Doppler ultrasonography: a possible new marker for diagnosis [J].

Pan, HA ;

Wu, MH ;

Cheng, YC ;

Li, CH ;

Chang, FM .

HUMAN REPRODUCTION, 2002, 17 (01) :201-206

[15] Laparoscopic treatment of polycystic ovaries: is it time to relinquish the procedure? [J].

Pirwany, I ;

Tulandi, T .

FERTILITY AND STERILITY, 2003, 80 (02) :241-251

[16] CHARACTERIZATION OF PELVIC ORGANS BY DOPPLER SONOGRAPHY WAVEFORM SHAPE [J].

Ronnie, Tepper ;

Yodfat, Shaharabany ;

Ron, Shiri ;

Hershkovitz, Reli .

ULTRASOUND IN MEDICINE AND BIOLOGY, 2010, 36 (05) :705-711

[17] Effects of laparoscopic ovarian drilling on serum vascular endothelial growth factor and on insulin responses to the oral glucose tolerance test in women with polycystic ovary syndrome [J].

Tulandi, T ;

Saleh, A ;

Morris, D ;

Jacobs, HS ;

Payne, NN ;

Tan, SL .

FERTILITY AND STERILITY, 2000, 74 (03) :585-588

[18] OVARIAN STROMAL BLOOD-FLOW IN WOMEN WITH POLYCYSTIC OVARIES - A POSSIBLE NEW MARKER FOR DIAGNOSIS [J].

ZAIDI, J ;

CAMPBELL, S ;

PITTROF, R ;

KYEIMENSAH, A ;

SHAKER, A ;

JACOBS, HS ;

TAN, SL .

HUMAN REPRODUCTION, 1995, 10 (08) :1992-1996

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