Effect of laparoscopic ovarian drilling on vascular endothelial growth factor and ovarian stromal blood flow using 3-dimensional power Doppler

被引：29
作者：
El Behery, Manal M. [1 ]
Diab, Abdalla E. [1 ]
Mowafy, Hala [1 ]
Ebrahiem, Moustafa A. [1 ]
Shehata, Amal E. [2 ]
机构：
[1] Zagazig Univ, Fac Med, Dept Obstet & Gynecol, Zagazig, Egypt
[2] Zagazig Univ, Fac Med, Dept Biochem, Zagazig, Egypt
来源：
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS | 2011年 / 112卷 / 02期
关键词：
3D power Doppler; Laparoscopic ovarian drilling; Polycystic ovary syndrome; Vascular endothelial growth factor; POLYCYSTIC-OVARY; WOMEN; ULTRASONOGRAPHY; DEFINITIONS; SONOGRAPHY; DIAGNOSIS; CONSENSUS; MARKER;
D O I：
10.1016/j.ijgo.2010.08.018
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: To determine, by using 3-dimensional power Doppler ultrasonography, the effect of laparoscopic ovarian drilling (LOD) on the serum level of vascular endothelial growth factor (VEGF) and ovarian stromal blood flow changes in polycystic ovary syndrome (PCOS). Methods: A prospective controlled clinical study was conducted on 26 clomiphene-resistant women with PCOS who were scheduled for LOD and a control group of 22 fertile regularly menstruating women. VEGF and 3 ovarian Doppler indices vascularization index, flow index, and vascularization flow index were measured and compared between the 2 groups, and before and after LOD in the PCOS group. Results: Serum VEGF and the Doppler indices of ovarian stromal blood flow were significantly higher in the PCOS group than in the control group. Serum VEGF and the ovarian stromal blood flow Doppler indices were significantly reduced in the PCOS group after LOD. Conclusion: Increased vascularity in PCOS demonstrated by Doppler blood flow measurements might be explained by the high level of VEGF. LOD reduced ovarian vascularization and serum VEGF. (C) 2010 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
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页码：119 / 121
页数：3
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