Eag and HERG potassium channels as novel therapeutic targets in cancer

被引：65

作者：

Asher, Viren ^{[1
]}

Sowter, Heidi ^{[2
]}

Shaw, Robert ^{[1
]}

Bali, Anish ^{[3
]}

Khan, Raheela ^{[1
]}

机构：

[1] Royal Derby Hosp, Sch Grad Med & Hlth, Dept Obstet & Gynaecol, Derby DE22 3DT, England

[2] Univ Derby, Derby DE22 1GB, England

[3] Royal Derby Hosp, Dept Obstet & Gynaecol, Derby DE22 3NE, England

来源：

WORLD JOURNAL OF SURGICAL ONCOLOGY | 2010年 / 8卷

关键词：

A-GO-GO; K+-CHANNELS; ION CHANNELS; HUMAN ETHER; ABERRANT EXPRESSION; CARDIAC-ARRHYTHMIA; UP-REGULATION; DROSOPHILA; VOLTAGE; CELLS;

D O I：

10.1186/1477-7819-8-113

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Voltage gated potassium channels have been extensively studied in relation to cancer. In this review, we will focus on the role of two potassium channels, Ether a-go-go (Eag), Human ether a-go-go related gene (HERG), in cancer and their potential therapeutic utility in the treatment of cancer. Eag and HERG are expressed in cancers of various organs and have been implicated in cell cycle progression and proliferation of cancer cells. Inhibition of these channels has been shown to reduce proliferation both in vitro and vivo studies identifying potassium channel modulators as putative inhibitors of tumour progression. Eag channels in view of their restricted expression in normal tissue may emerge as novel tumour biomarkers.

引用

页数：9

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