Synthesis of MoS2 nanosheets drug delivery system and its drug release behaviors

被引：2

作者：

Wang, Feng ^{[1
]}

Lv, Fang-Yuan ^{[1
]}

Liu, Kui-Long ^{[1
]}

Li, Zhi-Hao ^{[1
]}

Niu, Shu ^{[1
]}

Zhang, Yun-Yi ^{[1
]}

Cong, Hai-Lin ^{[1
,2
]}

Shen, You-Qing ^{[1
,2
]}

Yu, Bing ^{[1
,2
]}

机构：

[1] Qingdao Univ, Coll Mat Sci & Engn, Coll Chem & Chem Engn, Inst Biomed Mat & Engn, Qingdao, Peoples R China

[2] Qingdao Univ, State Key Lab Biofibers & Ecotext, Qingdao, Peoples R China

来源：

FERROELECTRICS | 2021年 / 578卷 / 01期

基金：

中国国家自然科学基金;

关键词：

MoS2; nanosheets; photothermal conversion; esterase-responsive; drug release;

D O I：

10.1080/00150193.2021.1902761

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

A MoS2 nanosheets drug delivery system with photothermal conversion ability was synthesized. The drug loading content of the synthesized was as high as 24.5%. The drug HCPT was modified by lipoic acid (LA) and connected onto MoS2 nanosheets through S-Mo bond, which is more stable than physical adsorption. Due to the ester bond between HCPT and MoS2 nanosheets, the drug delivery system could responsively release HCPT when exposed to esterase.

引用

页码：31 / 39

页数：9

共 20 条

[1] Low Cytotoxicity and Genotoxicity of Two-Dimensional MoS2 and WS2 [J].

Appel, Jennie H. ;

Li, Duo O. ;

Podlevsky, Joshua D. ;

Debnath, Abhishek ;

Green, Alexander A. ;

Wang, Qing Hua ;

Chae, Junseok .

ACS BIOMATERIALS SCIENCE & ENGINEERING, 2016, 2 (03) :361-367

[2] One-Pot Synthesis of MoS2 Nanoflakes with Desirable Degradability for Photothermal Cancer Therapy [J].

Chen, Liang ;

Feng, Yihan ;

Zhou, Xiaojun ;

Zhang, Qanqian ;

Nie, Wei ;

Wang, Weizhong ;

Zhang, Yanzhong ;

He, Chuanglong .

ACS APPLIED MATERIALS & INTERFACES, 2017, 9 (20) :17348-17359

[3] Chemically Exfoliated MoS2 as Near-Infrared Photothermal Agents [J].

Chou, Stanley S. ;

Kaehr, Bryan ;

Kim, Jaemyung ;

Foley, Brian M. ;

De, Mrinmoy ;

Hopkins, Patrick E. ;

Huang, Jiaxing ;

Brinker, C. Jeffrey ;

Dravid, Vinayak P. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013, 52 (15) :4160-4164

[4] Fast and Efficient Preparation of Exfoliated 2H MoS2 Nanosheets by Sonication-Assisted Lithium Intercalation and Infrared Laser-Induced 1T to 2H Phase Reversion [J].

Fan, Xiaobin ;

Xu, Pengtao ;

Zhou, Dekai ;

Sun, Yifan ;

Li, Yuguang C. ;

Nguyen, Minh An T. ;

Terrones, Mauricio ;

Mallouk, Thomas E. .

NANO LETTERS, 2015, 15 (09) :5956-5960

[5] Synthesis and biological evaluation of bis and monocarbonate prodrugs of 10-hydroxycamptothecins [J].

He, XG ;

Lu, W ;

Jiang, XQ ;

Cai, JC ;

Zhang, XW ;

Ding, J .

BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (15) :4003-4008

[6] One-step preparation of layered molybdenum disulfide/multi-walled carbon nanotube composites for enhanced performance supercapacitor [J].

Huang, Ke-Jing ;

Wang, Lan ;

Zhang, Ji-Zong ;

Wang, Ling-Ling ;

Mo, Yan-Ping .

ENERGY, 2014, 67 :234-240

[7] Drug-Loaded, Bivalent-Bottle-Brush Polymers by Graft-through ROMP [J].

Johnson, Jeremiah A. ;

Lu, Ying Y. ;

Burts, Alan O. ;

Xia, Yan ;

Durrell, Alec C. ;

Tirrell, David A. ;

Grubbs, Robert H. .

MACROMOLECULES, 2010, 43 (24) :10326-10335

[8] Preparation and Applications of Mechanically Exfoliated Single-Layer and Multi layer MoS2 and WSe2 Nanosheets [J].

Li, Hai ;

Wu, Jumiati ;

Yin, Zongyou ;

Zhang, Hua .

ACCOUNTS OF CHEMICAL RESEARCH, 2014, 47 (04) :1067-1075

[9] Drug Delivery with PEGylated MoS2 Nano-sheets for Combined Photothermal and Chemotherapy of Cancer [J].

Liu, Teng ;

Wang, Chao ;

Gu, Xing ;

Gong, Hua ;

Cheng, Liang ;

Shi, Xiaoze ;

Feng, Liangzhu ;

Sun, Baoquan ;

Liu, Zhuang .

ADVANCED MATERIALS, 2014, 26 (21) :3433-3440

[10] MoS2 and WS2 Analogues of Graphene [J].

Matte, H. S. S. Ramakrishna ;

Gomathi, A. ;

Manna, Arun K. ;

Late, Dattatray J. ;

Datta, Ranjan ;

Pati, Swapan K. ;

Rao, C. N. R. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 49 (24) :4059-4062

← 1 2 →