Synthesis and reactions of methyl 2-[3-(2-phenylquinazolin-4-yl)thioureido]alkanoates

被引：11

作者：

Fathalla, Walid ^{[1
]}

Pazdera, Pavel

机构：

[1] Suez Canal Univ, Fac Engn, Dept Math & Phys Sci, Port Said, Egypt

[2] Masaryk Univ, Fac Sci, Dept Organ Chem, CS-61137 Brno, Czech Republic

来源：

ARKIVOC | 2007年

关键词：

non-nucleoside RT inhibitors; quinazoline; thioureas; amino acids; imidoyl isothiocyanate;

D O I：

10.3998/ark.5550190.0008.125

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Quinazoline thioureas 5 bearing an amino acid ester residue were prepared by a novel three step sequential reaction of N-( 2- cyanophenyl) benzimidoyl isothioyanate with amino acid methyl ester hydrochlorides. Some chemoselective reactions of 5a with alkyl halides were studied.

引用

页码：236 / 243

页数：8

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